Ferroptosis open a new door for colorectal cancer treatment
Colorectal cancer (CRC) is the third highest incidence and the second highest mortality malignant tumor in the world. The etiology and pathogenesis of CRC are complex. Due to the long course of the disease and no obvious early symptoms, most patients are diagnosed as middle and late stages. CRC is p...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-03-01
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Series: | Frontiers in Oncology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1059520/full |
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author | Hong Liang Hong Liang Xia He Xia He Yitong Tong Niuniu Bai Niuniu Bai Yushu Pu Ke Han Ke Han Yi Wang |
author_facet | Hong Liang Hong Liang Xia He Xia He Yitong Tong Niuniu Bai Niuniu Bai Yushu Pu Ke Han Ke Han Yi Wang |
author_sort | Hong Liang |
collection | DOAJ |
description | Colorectal cancer (CRC) is the third highest incidence and the second highest mortality malignant tumor in the world. The etiology and pathogenesis of CRC are complex. Due to the long course of the disease and no obvious early symptoms, most patients are diagnosed as middle and late stages. CRC is prone to metastasis, most commonly liver metastasis, which is one of the leading causes of death in CRC patients. Ferroptosis is a newly discovered cell death form with iron dependence, which is driven by excessive lipid peroxides on the cell membrane. It is different from other form of programmed cell death in morphology and mechanism, such as apoptosis, pyroptosis and necroptosis. Numerous studies have shown that ferroptosis may play an important role in the development of CRC. For advanced or metastatic CRC, ferroptosis promises to open a new door in the setting of poor response to chemotherapy and targeted therapy. This mini review focuses on the pathogenesis of CRC, the mechanism of ferroptosis and the research status of ferroptosis in CRC treatment. The potential association between ferroptosis and CRC and some challenges are discussed. |
first_indexed | 2024-04-10T00:12:59Z |
format | Article |
id | doaj.art-2e94a32af25747d68c31e70660ad015e |
institution | Directory Open Access Journal |
issn | 2234-943X |
language | English |
last_indexed | 2024-04-10T00:12:59Z |
publishDate | 2023-03-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Oncology |
spelling | doaj.art-2e94a32af25747d68c31e70660ad015e2023-03-16T06:59:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.10595201059520Ferroptosis open a new door for colorectal cancer treatmentHong Liang0Hong Liang1Xia He2Xia He3Yitong Tong4Niuniu Bai5Niuniu Bai6Yushu Pu7Ke Han8Ke Han9Yi Wang10Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaChengdu Second People’s Hospital Party Committee Office, Chengdu, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Pharmacy, Shanxi Medical University, Taiyuan, ChinaNanchang University Queen Mary School, Nanchang, ChinaDepartment of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, The First People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sicuhan, ChinaColorectal cancer (CRC) is the third highest incidence and the second highest mortality malignant tumor in the world. The etiology and pathogenesis of CRC are complex. Due to the long course of the disease and no obvious early symptoms, most patients are diagnosed as middle and late stages. CRC is prone to metastasis, most commonly liver metastasis, which is one of the leading causes of death in CRC patients. Ferroptosis is a newly discovered cell death form with iron dependence, which is driven by excessive lipid peroxides on the cell membrane. It is different from other form of programmed cell death in morphology and mechanism, such as apoptosis, pyroptosis and necroptosis. Numerous studies have shown that ferroptosis may play an important role in the development of CRC. For advanced or metastatic CRC, ferroptosis promises to open a new door in the setting of poor response to chemotherapy and targeted therapy. This mini review focuses on the pathogenesis of CRC, the mechanism of ferroptosis and the research status of ferroptosis in CRC treatment. The potential association between ferroptosis and CRC and some challenges are discussed.https://www.frontiersin.org/articles/10.3389/fonc.2023.1059520/fullferroptosiscolorectal cancermolecular mechanisminducernanomedicine 1 |
spellingShingle | Hong Liang Hong Liang Xia He Xia He Yitong Tong Niuniu Bai Niuniu Bai Yushu Pu Ke Han Ke Han Yi Wang Ferroptosis open a new door for colorectal cancer treatment Frontiers in Oncology ferroptosis colorectal cancer molecular mechanism inducer nanomedicine 1 |
title | Ferroptosis open a new door for colorectal cancer treatment |
title_full | Ferroptosis open a new door for colorectal cancer treatment |
title_fullStr | Ferroptosis open a new door for colorectal cancer treatment |
title_full_unstemmed | Ferroptosis open a new door for colorectal cancer treatment |
title_short | Ferroptosis open a new door for colorectal cancer treatment |
title_sort | ferroptosis open a new door for colorectal cancer treatment |
topic | ferroptosis colorectal cancer molecular mechanism inducer nanomedicine 1 |
url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1059520/full |
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