Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

Human serum albumin (HSA) is the frontline antioxidant protein in blood with established anti-inflammatory and anticoagulation functions. Here, we report that COVID-19-induced oxidative stress inflicts structural damages to HSA and is linked with mortality outcome in critically ill patients. We recr...

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Bibliographic Details
Main Authors: Mohamed A Badawy, Basma A Yasseen, Riem M El-Messiery, Engy A Abdel-Rahman, Aya A Elkhodiry, Azza G Kamel, Hajar El-sayed, Asmaa M Shedra, Rehab Hamdy, Mona Zidan, Diaa Al-Raawi, Mahmoud Hammad, Nahla Elsharkawy, Mohamed El Ansary, Ahmed Al-Halfawy, Alaa Elhadad, Ashraf Hatem, Sherif Abouelnaga, Laura L Dugan, Sameh Saad Ali
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
critically ill COVID-19 patients
COVID-19 mortality
neutrophils
oxidative stress
human serum albumin damage
Online Access:https://elifesciences.org/articles/69417

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