Can Hyaluronic acid gel enhance wound healing faster than Advanced Platelets Rich Fibrin following surgical removal of impacted mandibular third molars? A Randomized Controlled Trial
The aim of this study: To assess the efficacy of advanced platelet-rich fibrin (A-PRF) and 1% hyaluronic acid gel (HA ) as a regenerative biomaterial for wound healing after impacted third molar extractions. Materials and methods: This study was a randomized controlled trial carried out in the oral...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
university of basrah
2023-12-01
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| Series: | Basrah Journal of Surgery |
| Subjects: | |
| Online Access: | https://bjsrg.uobasrah.edu.iq/article_181784.html |
| Summary: | The aim of this study: To assess the efficacy of advanced platelet-rich fibrin (A-PRF) and 1% hyaluronic acid gel (HA ) as a regenerative biomaterial for wound healing after impacted third molar extractions.
Materials and methods: This study was a randomized controlled trial carried out in the oral surgery unit of the dental teaching hospital. Furthermore, the participants were randomly assigned into three different groups. The patient's surgical site was left without adding any material in group A. While in group B (study group), the patient's surgical site was treated by applying a mixture of 1 cc HA gel with a one gel foam sponge. In group C (study group), the surgical site was treated by placing an A-PRF clot inside the surgical site. The first follow-up visit was 24 hours after the surgery to assess the soft tissue healing, with subsequent assessment visits on the third and seventh postoperative days.
Results: Hyaluronic acid and A-PRF groups, when compared with the control group, showed significant improvement in early wound healing scores. However, the A-PRF group had a statistically significant improvement over the hyaluronic acid group only during the first and third postoperative days.
Conclusion: Hyaluronic acid gel and A-PRF effectively enhanced early soft tissue healing following the surgical removal of the impacted lower third molar. with the upper hand for the A-PRF in the 1st and the 3rd postoperative days disappears in the 7th day.
Thus, the ease of availability of the Hyaluronic acid gel makes it an attractive alternative to the A-PRF.
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| ISSN: | 1683-3589 2409-501X |