Trends in antibiotic consumption in Colombian intensive care units, 2010-2017
Introduction: Antibiotics are frequently used in intensive care units (ICUs). Objective: To describe the trends of antibiotic use in Colombian ICUs across 8 years.Methods: This was a descriptive study that analyzed the consumption of antibiotics in 11 ICUs in 7 different cities. Data regarding antib...
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| Format: | Article |
| Language: | English |
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Asociación Colombiana de Infectología
2024-02-01
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| Series: | Infectio |
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| _version_ | 1797234094374912000 |
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| author | Jorge A. Sánchez-Duque |
| author_facet | Jorge A. Sánchez-Duque |
| author_sort | Jorge A. Sánchez-Duque |
| collection | DOAJ |
| description | Introduction: Antibiotics are frequently used in intensive care units (ICUs). Objective: To describe the trends of antibiotic use in Colombian ICUs across 8 years.Methods: This was a descriptive study that analyzed the consumption of antibiotics in 11 ICUs in 7 different cities. Data regarding antibiotic consumption during the period 2010 to 2017 were reviewed for patients older than 18 years. Demographic, pharmacological and cost variables were analyzed.Results: A total of 31,886 patients (50.8% men), with a mean age of 60.3±19.8 years, were treated with antibiotics. The most widely used antibiotics were pipera-cillin-tazobactam (25.2%), ampicillin-sulbactam (21.8%), and vancomycin (21.4%). The use of cefepime increased from 5.7 defined daily doses per 100 bed-days (DBD) in 2010 to 11.3 in 2017, followed by the use of meropenem (14.73 to 20.18 DBD). The average cost per patient/day decreased from USD 16.1 to USD 8.0 (reduction of 50.3%). From the total cost, 41.3% corresponded to meropenem and 25.8% to piperacillin-tazobactam.Conclusions: The antimicrobials used in the ICU correspond to those recommended by the clinical practice guidelines. An increase in the DBD of some cephalos-porins, carbapenems and penicillins and a significant reduction in the cost per patient day were observed. |
| first_indexed | 2024-04-24T16:26:36Z |
| format | Article |
| id | doaj.art-2e9858a5d7ce48fd877520e314840c43 |
| institution | Directory Open Access Journal |
| issn | 0123-9392 |
| language | English |
| last_indexed | 2024-04-24T16:26:36Z |
| publishDate | 2024-02-01 |
| publisher | Asociación Colombiana de Infectología |
| record_format | Article |
| series | Infectio |
| spelling | doaj.art-2e9858a5d7ce48fd877520e314840c432024-03-30T20:17:19ZengAsociación Colombiana de InfectologíaInfectio0123-93922024-02-012811926https://doi.org/10.22354/24223794.1163Trends in antibiotic consumption in Colombian intensive care units, 2010-2017Jorge A. Sánchez-Duque0https://orcid.org/0000-0002-8913-7729Grupo de Investigación Epidemiología, Salud y Violencia. Unidad de Epi-demiología, Departamento de Medicina Comunitaria, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira. Pereira, Colombia.Introduction: Antibiotics are frequently used in intensive care units (ICUs). Objective: To describe the trends of antibiotic use in Colombian ICUs across 8 years.Methods: This was a descriptive study that analyzed the consumption of antibiotics in 11 ICUs in 7 different cities. Data regarding antibiotic consumption during the period 2010 to 2017 were reviewed for patients older than 18 years. Demographic, pharmacological and cost variables were analyzed.Results: A total of 31,886 patients (50.8% men), with a mean age of 60.3±19.8 years, were treated with antibiotics. The most widely used antibiotics were pipera-cillin-tazobactam (25.2%), ampicillin-sulbactam (21.8%), and vancomycin (21.4%). The use of cefepime increased from 5.7 defined daily doses per 100 bed-days (DBD) in 2010 to 11.3 in 2017, followed by the use of meropenem (14.73 to 20.18 DBD). The average cost per patient/day decreased from USD 16.1 to USD 8.0 (reduction of 50.3%). From the total cost, 41.3% corresponded to meropenem and 25.8% to piperacillin-tazobactam.Conclusions: The antimicrobials used in the ICU correspond to those recommended by the clinical practice guidelines. An increase in the DBD of some cephalos-porins, carbapenems and penicillins and a significant reduction in the cost per patient day were observed.anti-bacterial agents; drugs costs; intensive care units; pharmacoepidemiology. |
| spellingShingle | Jorge A. Sánchez-Duque Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 Infectio anti-bacterial agents; drugs costs; intensive care units; pharmacoepidemiology. |
| title | Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 |
| title_full | Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 |
| title_fullStr | Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 |
| title_full_unstemmed | Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 |
| title_short | Trends in antibiotic consumption in Colombian intensive care units, 2010-2017 |
| title_sort | trends in antibiotic consumption in colombian intensive care units 2010 2017 |
| topic | anti-bacterial agents; drugs costs; intensive care units; pharmacoepidemiology. |
| work_keys_str_mv | AT jorgeasanchezduque trendsinantibioticconsumptionincolombianintensivecareunits20102017 |