Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections
Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/4/1046 |
| _version_ | 1797537107316572160 |
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| author | Yinghan Chan Xun Hui Wu Buong Woei Chieng Nor Azowa Ibrahim Yoon Yee Then |
| author_facet | Yinghan Chan Xun Hui Wu Buong Woei Chieng Nor Azowa Ibrahim Yoon Yee Then |
| author_sort | Yinghan Chan |
| collection | DOAJ |
| description | Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies. |
| first_indexed | 2024-03-10T12:10:22Z |
| format | Article |
| id | doaj.art-2e98cb6937a842c5a6348e82dd274439 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T12:10:22Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-2e98cb6937a842c5a6348e82dd2744392023-11-21T16:14:58ZengMDPI AGNanomaterials2079-49912021-04-01114104610.3390/nano11041046Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial InfectionsYinghan Chan0Xun Hui Wu1Buong Woei Chieng2Nor Azowa Ibrahim3Yoon Yee Then4Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur 57000, MalaysiaSchool of Postgraduate Studies, International Medical University (IMU), Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM), Serdang 43400, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia (UPM), Serdang 43400, MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur 57000, MalaysiaBiofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies.https://www.mdpi.com/2079-4991/11/4/1046biofilmpolymicrobial infectionsnosocomial infectionssuperhydrophobicnanomaterialsanti-biofilm surfaces |
| spellingShingle | Yinghan Chan Xun Hui Wu Buong Woei Chieng Nor Azowa Ibrahim Yoon Yee Then Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections Nanomaterials biofilm polymicrobial infections nosocomial infections superhydrophobic nanomaterials anti-biofilm surfaces |
| title | Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections |
| title_full | Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections |
| title_fullStr | Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections |
| title_full_unstemmed | Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections |
| title_short | Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections |
| title_sort | superhydrophobic nanocoatings as intervention against biofilm associated bacterial infections |
| topic | biofilm polymicrobial infections nosocomial infections superhydrophobic nanomaterials anti-biofilm surfaces |
| url | https://www.mdpi.com/2079-4991/11/4/1046 |
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