Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review
As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular sy...
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MDPI AG
2020-11-01
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2412 |
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| author | Gizem Kaykı-Mutlu Olga Papazisi Meindert Palmen A. H. Jan Danser Martin C. Michel Ebru Arioglu-Inan |
| author_facet | Gizem Kaykı-Mutlu Olga Papazisi Meindert Palmen A. H. Jan Danser Martin C. Michel Ebru Arioglu-Inan |
| author_sort | Gizem Kaykı-Mutlu |
| collection | DOAJ |
| description | As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α<sub>1</sub>-ARs in HF using 5 databases for our search. All three α<sub>1</sub>-AR subtypes (α<sub>1A</sub>, α<sub>1B</sub> and α<sub>1D</sub>) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α<sub>1</sub>-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α<sub>1</sub>-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α<sub>1</sub>-ARs. Whether α<sub>1</sub>-ARs are a therapeutic target in HF remains a matter of debate. |
| first_indexed | 2024-03-10T15:05:52Z |
| format | Article |
| id | doaj.art-2e9a819a32b149aaaf72d5025c8630b6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:05:52Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2e9a819a32b149aaaf72d5025c8630b62023-11-20T19:44:27ZengMDPI AGCells2073-44092020-11-01911241210.3390/cells9112412Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic ReviewGizem Kaykı-Mutlu0Olga Papazisi1Meindert Palmen2A. H. Jan Danser3Martin C. Michel4Ebru Arioglu-Inan5Department of Pharmacology, Faculty of Pharmacy, Ankara University, 06560 Ankara, TurkeyDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Internal Medicine, Division of Pharmacology, Erasmus Medical Center, 3000 CA Rotterdam, The NetherlandsDepartment of Pharmacology, Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Pharmacology, Faculty of Pharmacy, Ankara University, 06560 Ankara, TurkeyAs heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α<sub>1</sub>-ARs in HF using 5 databases for our search. All three α<sub>1</sub>-AR subtypes (α<sub>1A</sub>, α<sub>1B</sub> and α<sub>1D</sub>) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α<sub>1</sub>-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α<sub>1</sub>-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α<sub>1</sub>-ARs. Whether α<sub>1</sub>-ARs are a therapeutic target in HF remains a matter of debate.https://www.mdpi.com/2073-4409/9/11/2412α<sub>1</sub>-adrenoceptorscardiomyocyteblood vesselheart failure |
| spellingShingle | Gizem Kaykı-Mutlu Olga Papazisi Meindert Palmen A. H. Jan Danser Martin C. Michel Ebru Arioglu-Inan Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review Cells α<sub>1</sub>-adrenoceptors cardiomyocyte blood vessel heart failure |
| title | Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review |
| title_full | Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review |
| title_fullStr | Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review |
| title_full_unstemmed | Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review |
| title_short | Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review |
| title_sort | cardiac and vascular α sub 1 sub adrenoceptors in congestive heart failure a systematic review |
| topic | α<sub>1</sub>-adrenoceptors cardiomyocyte blood vessel heart failure |
| url | https://www.mdpi.com/2073-4409/9/11/2412 |
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