miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1
Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.855355/full |
| _version_ | 1811271889406918656 |
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| author | Jiexin Yan Lu Dai Jun Yuan Min Pang Yueqiu Wang Lang Lin Yawei Shi Fuli Wu Rongping Nie Qiuling Chen Lei Wang |
| author_facet | Jiexin Yan Lu Dai Jun Yuan Min Pang Yueqiu Wang Lang Lin Yawei Shi Fuli Wu Rongping Nie Qiuling Chen Lei Wang |
| author_sort | Jiexin Yan |
| collection | DOAJ |
| description | Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer in vivo and in vitro, while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer in vivo and in vitro by targeting TRIAP1. |
| first_indexed | 2024-04-12T22:30:21Z |
| format | Article |
| id | doaj.art-2e9af523ef304631815f632185d1061b |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T22:30:21Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-2e9af523ef304631815f632185d1061b2022-12-22T03:14:00ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.855355855355miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1Jiexin Yan0Lu Dai1Jun Yuan2Min Pang3Yueqiu Wang4Lang Lin5Yawei Shi6Fuli Wu7Rongping Nie8Qiuling Chen9Lei Wang10Emergency of Department, Changhai Hospital, Shanghai, ChinaThe Fourth Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaThe Fourth Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaEmergency of Department, Changhai Hospital, Shanghai, ChinaDepartment of Oral and Maxilliofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oral and Maxilliofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaThe Seventh Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, ChinaCangnan Hospital Affiliated to Wenzhou Medical University, Wenzhou, ChinaDepartment of Gastroenterology, Changhai Hospital, Shanghai, ChinaGastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer in vivo and in vitro, while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer in vivo and in vitro by targeting TRIAP1.https://www.frontiersin.org/articles/10.3389/fgene.2022.855355/fullgastric cancershort non-coding RNAcell proliferationcell invasionTRIAP1 |
| spellingShingle | Jiexin Yan Lu Dai Jun Yuan Min Pang Yueqiu Wang Lang Lin Yawei Shi Fuli Wu Rongping Nie Qiuling Chen Lei Wang miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 Frontiers in Genetics gastric cancer short non-coding RNA cell proliferation cell invasion TRIAP1 |
| title | miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 |
| title_full | miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 |
| title_fullStr | miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 |
| title_full_unstemmed | miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 |
| title_short | miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1 |
| title_sort | mir 107 inhibits the proliferation of gastric cancer cells in vivo and in vitro by targeting triap1 |
| topic | gastric cancer short non-coding RNA cell proliferation cell invasion TRIAP1 |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.855355/full |
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