Scavenger Receptor CD163 and Its Biological Functions
CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites. This scavenger rece...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2009-01-01
|
| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/52/2/0057/ |
| _version_ | 1817996793231704064 |
|---|---|
| author | Gabriela Onofre Martina Koláčková Karolína Jankovičová Jan Krejsek |
| author_facet | Gabriela Onofre Martina Koláčková Karolína Jankovičová Jan Krejsek |
| author_sort | Gabriela Onofre |
| collection | DOAJ |
| description | CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites. This scavenger receptor is selectively expressed on cells of monocytes and macrophages lineage exclusively. CD163 immunological function is essentially homeostatic. It also has other functions because participates in adhesion to endothelial cells, in tolerance induction and tissues regeneration. Other very important function of CD163 is the clearance of hemoglobin in its cell-free form and participation in anti-inflammation in its soluble form, exhibiting cytokine-like functions. We review the biological functions of CD163 which have been discovered until now. It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis. |
| first_indexed | 2024-04-14T02:27:19Z |
| format | Article |
| id | doaj.art-2e9b3065e710431b989219aced75de68 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-14T02:27:19Z |
| publishDate | 2009-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-2e9b3065e710431b989219aced75de682022-12-22T02:17:49ZengKarolinum PressActa Medica1211-42861805-96942009-01-01522576110.14712/18059694.2016.105Scavenger Receptor CD163 and Its Biological FunctionsGabriela Onofre0Martina Koláčková1Karolína Jankovičová2Jan Krejsek3Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites. This scavenger receptor is selectively expressed on cells of monocytes and macrophages lineage exclusively. CD163 immunological function is essentially homeostatic. It also has other functions because participates in adhesion to endothelial cells, in tolerance induction and tissues regeneration. Other very important function of CD163 is the clearance of hemoglobin in its cell-free form and participation in anti-inflammation in its soluble form, exhibiting cytokine-like functions. We review the biological functions of CD163 which have been discovered until now. It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis.https://actamedica.lfhk.cuni.cz/52/2/0057/CD163Scavenger receptorHemoglobinHaptoglobinFunctions |
| spellingShingle | Gabriela Onofre Martina Koláčková Karolína Jankovičová Jan Krejsek Scavenger Receptor CD163 and Its Biological Functions Acta Medica CD163 Scavenger receptor Hemoglobin Haptoglobin Functions |
| title | Scavenger Receptor CD163 and Its Biological Functions |
| title_full | Scavenger Receptor CD163 and Its Biological Functions |
| title_fullStr | Scavenger Receptor CD163 and Its Biological Functions |
| title_full_unstemmed | Scavenger Receptor CD163 and Its Biological Functions |
| title_short | Scavenger Receptor CD163 and Its Biological Functions |
| title_sort | scavenger receptor cd163 and its biological functions |
| topic | CD163 Scavenger receptor Hemoglobin Haptoglobin Functions |
| url | https://actamedica.lfhk.cuni.cz/52/2/0057/ |
| work_keys_str_mv | AT gabrielaonofre scavengerreceptorcd163anditsbiologicalfunctions AT martinakolackova scavengerreceptorcd163anditsbiologicalfunctions AT karolinajankovicova scavengerreceptorcd163anditsbiologicalfunctions AT jankrejsek scavengerreceptorcd163anditsbiologicalfunctions |