Fast-Growing Alveolar Echinococcosis Following Lung Transplantation
Alveolar echinococcosis is a rare but life-threatening infection caused by the parasite <i>Echinococcus multilocularis</i>. Its natural history is characterized by a slow parasitic growth over several years. Increased incidence and shorter development delay have been reported in immune-c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/9/756 |
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| author | Clarisse Dupont Fréderic Grenouillet Jean-Yves Mabrut Frédérique Gay Florence Persat Martine Wallon Jean-François Mornex François Philit Damien Dupont |
| author_facet | Clarisse Dupont Fréderic Grenouillet Jean-Yves Mabrut Frédérique Gay Florence Persat Martine Wallon Jean-François Mornex François Philit Damien Dupont |
| author_sort | Clarisse Dupont |
| collection | DOAJ |
| description | Alveolar echinococcosis is a rare but life-threatening infection caused by the parasite <i>Echinococcus multilocularis</i>. Its natural history is characterized by a slow parasitic growth over several years. Increased incidence and shorter development delay have been reported in immune-compromised patients. We report the reactivation of aborted lesions within 12 months of lung transplantation leading to a fast-growing aggressive hepatic lesion. Timely identification of alveolar echninococcosis allowed prompt albendazole treatment and radical surgery leading to a favorable outcome 42 months after transplantation. However, close clinical, serological and radiological monitoring is required to rule out relapses in the long term. The pre-existence of aborted self-limited lesions of alveolar echinococcosis and the possibility for their atypical rapid growth in patients undergoing profound immunosuppression should be known by healthcare providers, even if working in non-endemic areas. |
| first_indexed | 2024-03-10T16:16:46Z |
| format | Article |
| id | doaj.art-2e9dd918228842c788e6d705199f7ec6 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T16:16:46Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-2e9dd918228842c788e6d705199f7ec62023-11-20T13:58:31ZengMDPI AGPathogens2076-08172020-09-019975610.3390/pathogens9090756Fast-Growing Alveolar Echinococcosis Following Lung TransplantationClarisse Dupont0Fréderic Grenouillet1Jean-Yves Mabrut2Frédérique Gay3Florence Persat4Martine Wallon5Jean-François Mornex6François Philit7Damien Dupont8Service de Pneumologie, Hôpital Louis Pradel, Hospices Civils de Lyon, 69500 Bron, FranceUnité de Sérologies Parasitaires et Fongiques, Laboratoire de Biologie Médicale, Centre Hospitalier Régional Universitaire, 25000 Besançon, FranceService de Chirurgie Digestive et de Transplantation Hépatique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69317 Lyon, FranceService de Radiologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69003 Lyon, FranceInstitut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69317 Lyon, FranceInstitut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69317 Lyon, FranceService de Pneumologie, Hôpital Louis Pradel, Hospices Civils de Lyon, 69500 Bron, FranceService de Pneumologie, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69317 Lyon, FranceInstitut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69317 Lyon, FranceAlveolar echinococcosis is a rare but life-threatening infection caused by the parasite <i>Echinococcus multilocularis</i>. Its natural history is characterized by a slow parasitic growth over several years. Increased incidence and shorter development delay have been reported in immune-compromised patients. We report the reactivation of aborted lesions within 12 months of lung transplantation leading to a fast-growing aggressive hepatic lesion. Timely identification of alveolar echninococcosis allowed prompt albendazole treatment and radical surgery leading to a favorable outcome 42 months after transplantation. However, close clinical, serological and radiological monitoring is required to rule out relapses in the long term. The pre-existence of aborted self-limited lesions of alveolar echinococcosis and the possibility for their atypical rapid growth in patients undergoing profound immunosuppression should be known by healthcare providers, even if working in non-endemic areas.https://www.mdpi.com/2076-0817/9/9/756<i>Echinococcus multilocularis</i>parasiteliverlung transplantationimmunosuppression |
| spellingShingle | Clarisse Dupont Fréderic Grenouillet Jean-Yves Mabrut Frédérique Gay Florence Persat Martine Wallon Jean-François Mornex François Philit Damien Dupont Fast-Growing Alveolar Echinococcosis Following Lung Transplantation Pathogens <i>Echinococcus multilocularis</i> parasite liver lung transplantation immunosuppression |
| title | Fast-Growing Alveolar Echinococcosis Following Lung Transplantation |
| title_full | Fast-Growing Alveolar Echinococcosis Following Lung Transplantation |
| title_fullStr | Fast-Growing Alveolar Echinococcosis Following Lung Transplantation |
| title_full_unstemmed | Fast-Growing Alveolar Echinococcosis Following Lung Transplantation |
| title_short | Fast-Growing Alveolar Echinococcosis Following Lung Transplantation |
| title_sort | fast growing alveolar echinococcosis following lung transplantation |
| topic | <i>Echinococcus multilocularis</i> parasite liver lung transplantation immunosuppression |
| url | https://www.mdpi.com/2076-0817/9/9/756 |
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