Obesity Paradox in Lung Diseases: What Explains It?
Background: Obesity is a globally increasing health problem that impacts multiple organ systems and a potentially modifiable risk factor for many diseases. Obesity has a significant impact on lung function and is strongly linked to the pathophysiology that contributes to lung diseases. On the other...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-07-01
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| Series: | Obesity Facts |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/531792 |
| _version_ | 1828717895909113856 |
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| author | Surui Yao Lei Zeng Fengyuan Wang Kejie Chen |
| author_facet | Surui Yao Lei Zeng Fengyuan Wang Kejie Chen |
| author_sort | Surui Yao |
| collection | DOAJ |
| description | Background: Obesity is a globally increasing health problem that impacts multiple organ systems and a potentially modifiable risk factor for many diseases. Obesity has a significant impact on lung function and is strongly linked to the pathophysiology that contributes to lung diseases. On the other hand, reports have emerged that obesity is associated with a better prognosis than for normal weight individuals in some lung diseases, including pneumonia, acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, and lung cancer. The lesser mortality and better prognosis in patients with obesity is known as obesity paradox. While obesity paradox is both recognized and disputed in epidemiological studies, recent research has suggested possible mechanisms. Summary: In this review, we attempted to explain and summarize these factors and mechanisms, including immune response, pulmonary fibrosis, lung function, microbiota, fat and muscle reserves, which are significantly altered by obesity and may contribute to the obesity paradox in lung diseases. We also discuss contrary literature that attributes the “obesity paradox” to confounding. Key Messages: The review will illustrate the possible role of obesity in the prognosis or course of lung diseases, leading to a better understanding of the obesity paradox and provide hints for further basic and clinical research in lung diseases. |
| first_indexed | 2024-03-12T14:35:02Z |
| format | Article |
| id | doaj.art-2ea0e8bfa4484a08b9717cafc7a0417d |
| institution | Directory Open Access Journal |
| issn | 1662-4033 |
| language | English |
| last_indexed | 2024-03-12T14:35:02Z |
| publishDate | 2023-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-2ea0e8bfa4484a08b9717cafc7a0417d2023-08-17T08:59:57ZengKarger PublishersObesity Facts1662-40332023-07-0111610.1159/000531792531792Obesity Paradox in Lung Diseases: What Explains It?Surui Yao0Lei Zeng1https://orcid.org/0000-0002-0868-131XFengyuan Wang2Kejie Chen3School of Public Health, Chengdu Medical College, Chengdu, ChinaSchool of Public Health, Chengdu Medical College, Chengdu, ChinaCollege of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu, ChinaSchool of Public Health, Chengdu Medical College, Chengdu, ChinaBackground: Obesity is a globally increasing health problem that impacts multiple organ systems and a potentially modifiable risk factor for many diseases. Obesity has a significant impact on lung function and is strongly linked to the pathophysiology that contributes to lung diseases. On the other hand, reports have emerged that obesity is associated with a better prognosis than for normal weight individuals in some lung diseases, including pneumonia, acute lung injury/acute respiratory distress syndrome, chronic obstructive pulmonary disease, and lung cancer. The lesser mortality and better prognosis in patients with obesity is known as obesity paradox. While obesity paradox is both recognized and disputed in epidemiological studies, recent research has suggested possible mechanisms. Summary: In this review, we attempted to explain and summarize these factors and mechanisms, including immune response, pulmonary fibrosis, lung function, microbiota, fat and muscle reserves, which are significantly altered by obesity and may contribute to the obesity paradox in lung diseases. We also discuss contrary literature that attributes the “obesity paradox” to confounding. Key Messages: The review will illustrate the possible role of obesity in the prognosis or course of lung diseases, leading to a better understanding of the obesity paradox and provide hints for further basic and clinical research in lung diseases.https://beta.karger.com/Article/FullText/531792pneumoniaacute lung injuryacute respiratory distress syndromechronic obstructive pulmonary diseaselung cancerobesity paradox |
| spellingShingle | Surui Yao Lei Zeng Fengyuan Wang Kejie Chen Obesity Paradox in Lung Diseases: What Explains It? Obesity Facts pneumonia acute lung injury acute respiratory distress syndrome chronic obstructive pulmonary disease lung cancer obesity paradox |
| title | Obesity Paradox in Lung Diseases: What Explains It? |
| title_full | Obesity Paradox in Lung Diseases: What Explains It? |
| title_fullStr | Obesity Paradox in Lung Diseases: What Explains It? |
| title_full_unstemmed | Obesity Paradox in Lung Diseases: What Explains It? |
| title_short | Obesity Paradox in Lung Diseases: What Explains It? |
| title_sort | obesity paradox in lung diseases what explains it |
| topic | pneumonia acute lung injury acute respiratory distress syndrome chronic obstructive pulmonary disease lung cancer obesity paradox |
| url | https://beta.karger.com/Article/FullText/531792 |
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