History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence
(1) Background: Cerebral autoregulation is altered during acute mild traumatic brain injury, or concussion. However, it is unknown how a history of concussion can impact cerebral haemodynamic activity during a task that elicits an autoregulatory response. (2) Methods: We assessed cerebral haemodynam...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/11/1443 |
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| author | J. Patrick Neary Jyotpal Singh Luke W. Sirant Catherine A. Gaul Steve Martin Lynneth Stuart-Hill Darren G. Candow Cameron S. Mang Gregory P. Kratzig |
| author_facet | J. Patrick Neary Jyotpal Singh Luke W. Sirant Catherine A. Gaul Steve Martin Lynneth Stuart-Hill Darren G. Candow Cameron S. Mang Gregory P. Kratzig |
| author_sort | J. Patrick Neary |
| collection | DOAJ |
| description | (1) Background: Cerebral autoregulation is altered during acute mild traumatic brain injury, or concussion. However, it is unknown how a history of concussion can impact cerebral haemodynamic activity during a task that elicits an autoregulatory response. (2) Methods: We assessed cerebral haemodynamic activity in those with a history of three or more concussions. The study included 44 retired athletes with concussion history and 25 control participants. We recorded participants’ relative changes in right and left pre-frontal cortex oxygenation collected by near-infrared spectroscopy and continuous beat-to-beat blood pressure measured by finger photoplethysmography. Participants completed a 5-min seated rest followed by a 5-min repeated squat (10-s) stand (10-s) maneuver (0.05 Hz) to elicit a cerebral autoregulatory response. Wavelet transformation was applied to the collected signals, allowing separation into cardiac interval I (0.6 to 2 Hz), respiratory interval II (0.145 to 0.6 Hz), and smooth muscle cell interval III (0.052 to 0.145 Hz). (3) Results: Significant increases at cardiac interval I were found for the wavelet amplitude of oxy-haemoglobin and haemoglobin difference at the right pre-frontal cortex. No significant difference was found at the left pre-frontal cortex or the blood pressure wavelet amplitudes. (4) Conclusions: Contributions from cardiac activity to the pre-frontal cortex oxygenation are elevated when eliciting dynamic cerebral autoregulation in those with a history of three or more concussions. |
| first_indexed | 2024-03-09T19:13:58Z |
| format | Article |
| id | doaj.art-2ea11ca38ec14e20bde5ec37bb0ceb81 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T19:13:58Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2ea11ca38ec14e20bde5ec37bb0ceb812023-11-24T03:56:02ZengMDPI AGBrain Sciences2076-34252022-10-011211144310.3390/brainsci12111443History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac InfluenceJ. Patrick Neary0Jyotpal Singh1Luke W. Sirant2Catherine A. Gaul3Steve Martin4Lynneth Stuart-Hill5Darren G. Candow6Cameron S. Mang7Gregory P. Kratzig8Faculty of Kinesiology & Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaFaculty of Kinesiology & Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaFaculty of Kinesiology & Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaSchool of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC V8P 5C2, CanadaSchool of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC V8P 5C2, CanadaSchool of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC V8P 5C2, CanadaFaculty of Kinesiology & Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaFaculty of Kinesiology & Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaDepartment of Psychology, University of Regina, Regina, SK S4S 0A2, Canada(1) Background: Cerebral autoregulation is altered during acute mild traumatic brain injury, or concussion. However, it is unknown how a history of concussion can impact cerebral haemodynamic activity during a task that elicits an autoregulatory response. (2) Methods: We assessed cerebral haemodynamic activity in those with a history of three or more concussions. The study included 44 retired athletes with concussion history and 25 control participants. We recorded participants’ relative changes in right and left pre-frontal cortex oxygenation collected by near-infrared spectroscopy and continuous beat-to-beat blood pressure measured by finger photoplethysmography. Participants completed a 5-min seated rest followed by a 5-min repeated squat (10-s) stand (10-s) maneuver (0.05 Hz) to elicit a cerebral autoregulatory response. Wavelet transformation was applied to the collected signals, allowing separation into cardiac interval I (0.6 to 2 Hz), respiratory interval II (0.145 to 0.6 Hz), and smooth muscle cell interval III (0.052 to 0.145 Hz). (3) Results: Significant increases at cardiac interval I were found for the wavelet amplitude of oxy-haemoglobin and haemoglobin difference at the right pre-frontal cortex. No significant difference was found at the left pre-frontal cortex or the blood pressure wavelet amplitudes. (4) Conclusions: Contributions from cardiac activity to the pre-frontal cortex oxygenation are elevated when eliciting dynamic cerebral autoregulation in those with a history of three or more concussions.https://www.mdpi.com/2076-3425/12/11/1443concussioncerebral autoregulationpre-frontal cortex oxygenationblood pressurewavelet transformation |
| spellingShingle | J. Patrick Neary Jyotpal Singh Luke W. Sirant Catherine A. Gaul Steve Martin Lynneth Stuart-Hill Darren G. Candow Cameron S. Mang Gregory P. Kratzig History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence Brain Sciences concussion cerebral autoregulation pre-frontal cortex oxygenation blood pressure wavelet transformation |
| title | History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence |
| title_full | History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence |
| title_fullStr | History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence |
| title_full_unstemmed | History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence |
| title_short | History of Brain Injury Alters Cerebral Haemodynamic Oscillations with Cardiac Influence |
| title_sort | history of brain injury alters cerebral haemodynamic oscillations with cardiac influence |
| topic | concussion cerebral autoregulation pre-frontal cortex oxygenation blood pressure wavelet transformation |
| url | https://www.mdpi.com/2076-3425/12/11/1443 |
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