Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer

Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer

Radiotherapy is an important component of current treatment options for colorectal cancer (CRC). It is either applied as neoadjuvant radiotherapy to improve local disease control in rectal cancers or for the treatment of localized metastatic lesions of CRC. DNA double-strand breaks (DSBs) are the ma...

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Bibliographic Details
Main Authors: Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R. Veldwijk, Carsten Herskind
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
colorectal cancer
radiosensitivity
DNA damage response
DNA repair
cell-cycle checkpoint inhibitors
Online Access:https://www.mdpi.com/2072-6694/14/19/4874

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