Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy
Heart failure (HF) is associated with endothelial dysfunction. Vascular function per se plays an important role in cardiac function, whether it is a cause or consequence. However, there is no information on vascular function in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM)...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/7/2534 |
| _version_ | 1797607632009166848 |
|---|---|
| author | Yu Hashimoto Takayuki Yamaji Toshiro Kitagawa Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Kazuaki Chayama Chikara Goto Syunsuke Tanigawa Aya Mizobuchi Takahiro Harada Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Asuka Fujita Toshio Uchiki Ayumu Nakashima Yukihito Higashi |
| author_facet | Yu Hashimoto Takayuki Yamaji Toshiro Kitagawa Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Kazuaki Chayama Chikara Goto Syunsuke Tanigawa Aya Mizobuchi Takahiro Harada Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Asuka Fujita Toshio Uchiki Ayumu Nakashima Yukihito Higashi |
| author_sort | Yu Hashimoto |
| collection | DOAJ |
| description | Heart failure (HF) is associated with endothelial dysfunction. Vascular function per se plays an important role in cardiac function, whether it is a cause or consequence. However, there is no information on vascular function in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). The purpose of this study was to evaluate vascular function in patients with ATTRwt-CM. We measured flow-mediated vasodilation (FMD) as an index of endothelial function and nitroglycerine-induced vasodilation (NID) as an index of vascular smooth muscle function and brachial artery intima-media thickness (bIMT) and brachial-ankle pulse wave velocity (baPWV) as indices of arterial stiffness in 22 patients with ATTRwt-CM and in 22 one-by-one matched control patients using vascular function confounding factors. FMD was significantly greater in patients with ATTRwt-CM than in the controls (5.4 ± 3.4% versus 3.5 ± 2.4%, <i>p</i> = 0.038) and the N-terminal pro-brain natriuretic peptide (NT-proBNP) level was significantly greater in patients with ATTRwt-CM than in the controls (2202 ± 1478 versus 470 ± 677 pg/mL, <i>p</i> < 0.001). There were no significant differences in NID, bIMT or baPWV between the two groups. There was a significant relationship between NT-proBNP and FMD in patients with ATTRwt-CM (r = 0.485, <i>p</i> = 0.022). NT-proBNP showed no significant relationships with NID, bIMT or baPWV. Conclusions: Endothelial function was preserved in patients with ATTRwt-CM. Patients with ATTRwt-CM may have compensatory effects with respect to endothelial function through elevation of BNP. |
| first_indexed | 2024-03-11T05:32:35Z |
| format | Article |
| id | doaj.art-2ea48a7d634e47d8904064f1f505b88b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:32:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2ea48a7d634e47d8904064f1f505b88b2023-11-17T16:58:27ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01127253410.3390/jcm12072534Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid CardiomyopathyYu Hashimoto0Takayuki Yamaji1Toshiro Kitagawa2Yukiko Nakano3Masato Kajikawa4Kenichi Yoshimura5Kazuaki Chayama6Chikara Goto7Syunsuke Tanigawa8Aya Mizobuchi9Takahiro Harada10Farina Mohamad Yusoff11Shinji Kishimoto12Tatsuya Maruhashi13Asuka Fujita14Toshio Uchiki15Ayumu Nakashima16Yukihito Higashi17Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of Biostatistics, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanCollaborative Research Laboratory of Medical Innovation, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Physical Therapy, Hiroshima International University, Hiroshima 737-0112, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 739-8529, JapanDepartment of Stem Cell Biology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanHeart failure (HF) is associated with endothelial dysfunction. Vascular function per se plays an important role in cardiac function, whether it is a cause or consequence. However, there is no information on vascular function in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). The purpose of this study was to evaluate vascular function in patients with ATTRwt-CM. We measured flow-mediated vasodilation (FMD) as an index of endothelial function and nitroglycerine-induced vasodilation (NID) as an index of vascular smooth muscle function and brachial artery intima-media thickness (bIMT) and brachial-ankle pulse wave velocity (baPWV) as indices of arterial stiffness in 22 patients with ATTRwt-CM and in 22 one-by-one matched control patients using vascular function confounding factors. FMD was significantly greater in patients with ATTRwt-CM than in the controls (5.4 ± 3.4% versus 3.5 ± 2.4%, <i>p</i> = 0.038) and the N-terminal pro-brain natriuretic peptide (NT-proBNP) level was significantly greater in patients with ATTRwt-CM than in the controls (2202 ± 1478 versus 470 ± 677 pg/mL, <i>p</i> < 0.001). There were no significant differences in NID, bIMT or baPWV between the two groups. There was a significant relationship between NT-proBNP and FMD in patients with ATTRwt-CM (r = 0.485, <i>p</i> = 0.022). NT-proBNP showed no significant relationships with NID, bIMT or baPWV. Conclusions: Endothelial function was preserved in patients with ATTRwt-CM. Patients with ATTRwt-CM may have compensatory effects with respect to endothelial function through elevation of BNP.https://www.mdpi.com/2077-0383/12/7/2534endothelial functionflow-mediated vasodilationwild-type transthyretin amyloidosis cardiomyopathyN-terminal pro-brain natriuretic peptide |
| spellingShingle | Yu Hashimoto Takayuki Yamaji Toshiro Kitagawa Yukiko Nakano Masato Kajikawa Kenichi Yoshimura Kazuaki Chayama Chikara Goto Syunsuke Tanigawa Aya Mizobuchi Takahiro Harada Farina Mohamad Yusoff Shinji Kishimoto Tatsuya Maruhashi Asuka Fujita Toshio Uchiki Ayumu Nakashima Yukihito Higashi Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy Journal of Clinical Medicine endothelial function flow-mediated vasodilation wild-type transthyretin amyloidosis cardiomyopathy N-terminal pro-brain natriuretic peptide |
| title | Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy |
| title_full | Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy |
| title_fullStr | Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy |
| title_full_unstemmed | Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy |
| title_short | Endothelial Function Is Preserved in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy |
| title_sort | endothelial function is preserved in patients with wild type transthyretin amyloid cardiomyopathy |
| topic | endothelial function flow-mediated vasodilation wild-type transthyretin amyloidosis cardiomyopathy N-terminal pro-brain natriuretic peptide |
| url | https://www.mdpi.com/2077-0383/12/7/2534 |
| work_keys_str_mv | AT yuhashimoto endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT takayukiyamaji endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT toshirokitagawa endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT yukikonakano endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT masatokajikawa endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT kenichiyoshimura endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT kazuakichayama endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT chikaragoto endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT syunsuketanigawa endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT ayamizobuchi endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT takahiroharada endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT farinamohamadyusoff endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT shinjikishimoto endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT tatsuyamaruhashi endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT asukafujita endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT toshiouchiki endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT ayumunakashima endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy AT yukihitohigashi endothelialfunctionispreservedinpatientswithwildtypetransthyretinamyloidcardiomyopathy |