Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients.
<h4>Background</h4>Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was a novel marker of liver fibrosis. We aimed to investigate WFA+-M2BP level in assessing liver fibrosis in patients with chronic hepatitis B (CHB) infection.<h4>Methods</h4>A total...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0220663 |
| _version_ | 1819037061913509888 |
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| author | Ming-Lun Yeh Chung-Feng Huang Ching-I Huang Chia-Yen Dai I-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Zu-Yau Lin Shinn-Chern Chen Jee-Fu Huang Jyh-Jou Chen Ming-Lung Yu Wan-Long Chuang |
| author_facet | Ming-Lun Yeh Chung-Feng Huang Ching-I Huang Chia-Yen Dai I-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Zu-Yau Lin Shinn-Chern Chen Jee-Fu Huang Jyh-Jou Chen Ming-Lung Yu Wan-Long Chuang |
| author_sort | Ming-Lun Yeh |
| collection | DOAJ |
| description | <h4>Background</h4>Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was a novel marker of liver fibrosis. We aimed to investigate WFA+-M2BP level in assessing liver fibrosis in patients with chronic hepatitis B (CHB) infection.<h4>Methods</h4>A total of 160 CHB patients, who received a liver biopsy, were consecutively recruited. Serum WFA+-M2BP level was quantified at the time point of biopsy. The results were compared with histopathological manifestations and clinical characteristics of the patients.<h4>Results</h4>The median WFA+-M2BP level, aspartate aminotransferase-to-platelet ratio (APRI) and Fibrosis-4 (FIB-4) index were 1.20 COI, 1.19, and 1.63, respectively. Fifty-one (31.9%) patients had advanced fibrosis. There was a significant increase of WFA+-M2BP levels in parallel to necroinflammation/fibrosis stages. The areas under the receiver operating characteristic curve (AUROC) of WFA+-M2BP level for predicting fibrosis stages were 0.780 of F2, 0.785 of F3, and 0.769 of F4, respectively (all p <0.001). The multivariate analysis identified age (Odds ratio [OR] 1.05, 95% confidence interval [CI]: 1.010-1.092, p = 0.014), platelet (OR: 0.99, 95%CI: 0.980-0.998, p = 0.013), and WFA+-M2BP level (OR: 1.97, 95% CI: 1.299-2.984, p = 0.001) as independent factors associated with advanced fibrosis. Combination of age, platelet and WFA+-M2BP level achieved a better diagnostic performance for advanced fibrosis (AUROC: 0.732, accuracy: 81.3%) than APRI (AUROC: 0.577, accuracy: 63.8%) or FIB-4 index (AUROC: 0.691, accuracy: 75.6%).<h4>Conclusion</h4>WFA+-M2BP had a good performance indistinguishing liver fibrosis in CHB patients. The combination of age, platelet, and WFA+-M2BPaddressed more accuracy in identifying patients with advanced fibrosis. |
| first_indexed | 2024-12-21T08:15:26Z |
| format | Article |
| id | doaj.art-2ea584e6450b486d95b8d1bbbd8d0c75 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T08:15:26Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2ea584e6450b486d95b8d1bbbd8d0c752022-12-21T19:10:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01148e022066310.1371/journal.pone.0220663Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients.Ming-Lun YehChung-Feng HuangChing-I HuangChia-Yen DaiI-Hung LinPo-Cheng LiangMeng-Hsuan HsiehZu-Yau LinShinn-Chern ChenJee-Fu HuangJyh-Jou ChenMing-Lung YuWan-Long Chuang<h4>Background</h4>Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) was a novel marker of liver fibrosis. We aimed to investigate WFA+-M2BP level in assessing liver fibrosis in patients with chronic hepatitis B (CHB) infection.<h4>Methods</h4>A total of 160 CHB patients, who received a liver biopsy, were consecutively recruited. Serum WFA+-M2BP level was quantified at the time point of biopsy. The results were compared with histopathological manifestations and clinical characteristics of the patients.<h4>Results</h4>The median WFA+-M2BP level, aspartate aminotransferase-to-platelet ratio (APRI) and Fibrosis-4 (FIB-4) index were 1.20 COI, 1.19, and 1.63, respectively. Fifty-one (31.9%) patients had advanced fibrosis. There was a significant increase of WFA+-M2BP levels in parallel to necroinflammation/fibrosis stages. The areas under the receiver operating characteristic curve (AUROC) of WFA+-M2BP level for predicting fibrosis stages were 0.780 of F2, 0.785 of F3, and 0.769 of F4, respectively (all p <0.001). The multivariate analysis identified age (Odds ratio [OR] 1.05, 95% confidence interval [CI]: 1.010-1.092, p = 0.014), platelet (OR: 0.99, 95%CI: 0.980-0.998, p = 0.013), and WFA+-M2BP level (OR: 1.97, 95% CI: 1.299-2.984, p = 0.001) as independent factors associated with advanced fibrosis. Combination of age, platelet and WFA+-M2BP level achieved a better diagnostic performance for advanced fibrosis (AUROC: 0.732, accuracy: 81.3%) than APRI (AUROC: 0.577, accuracy: 63.8%) or FIB-4 index (AUROC: 0.691, accuracy: 75.6%).<h4>Conclusion</h4>WFA+-M2BP had a good performance indistinguishing liver fibrosis in CHB patients. The combination of age, platelet, and WFA+-M2BPaddressed more accuracy in identifying patients with advanced fibrosis.https://doi.org/10.1371/journal.pone.0220663 |
| spellingShingle | Ming-Lun Yeh Chung-Feng Huang Ching-I Huang Chia-Yen Dai I-Hung Lin Po-Cheng Liang Meng-Hsuan Hsieh Zu-Yau Lin Shinn-Chern Chen Jee-Fu Huang Jyh-Jou Chen Ming-Lung Yu Wan-Long Chuang Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. PLoS ONE |
| title | Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. |
| title_full | Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. |
| title_fullStr | Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. |
| title_full_unstemmed | Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. |
| title_short | Wisteria floribunda agglutinin-positive Mac-2-binding protein in the prediction of disease severity in chronic hepatitis B patients. |
| title_sort | wisteria floribunda agglutinin positive mac 2 binding protein in the prediction of disease severity in chronic hepatitis b patients |
| url | https://doi.org/10.1371/journal.pone.0220663 |
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