Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson’s Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation

Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson’s Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation

Parkinson’s disease (PD) is a socially significant disease, during the development of which oxidative stress and inflammation play a significant role. Here, we studied the neuroprotective effects of four Kunitz-type peptides from <i>Heteractis crispa</i> and <i>Heteractis magnifica...

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Bibliographic Details
Main Authors: Aleksandra Kvetkina, Evgeny Pislyagin, Ekaterina Menchinskaya, Ekaterina Yurchenko, Rimma Kalina, Sergei Kozlovskiy, Leonid Kaluzhskiy, Alexander Menshov, Natalia Kim, Steve Peigneur, Jan Tytgat, Alexis Ivanov, Naira Ayvazyan, Elena Leychenko, Dmitry Aminin
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
Kunitz-type peptides
neuroprotective activity
sea anemones
TRPV1
P2X7R
Parkinson’s disease (PD)
Online Access:https://www.mdpi.com/1422-0067/23/9/5115

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