Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal
Background: Previous research has studied the rate of hepatitis C virus (HCV) coinfection among HIV-positive people regardless of their antiretroviral therapy (ART) status. Our objectives were to measure the seroprevalence of HCV both in HIV-positive people receiving ART and in those not receiving A...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-05-01
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| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325957413500989 |
| _version_ | 1818043036799598592 |
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| author | Krishna C. Poudel PhD, MHSc Paula H. Palmer PhD Masamine Jimba MD Tetsuya Mizoue MD, PhD Jun Kobayashi MD, PhD Kalpana Poudel-Tandukar PhD, MPH |
| author_facet | Krishna C. Poudel PhD, MHSc Paula H. Palmer PhD Masamine Jimba MD Tetsuya Mizoue MD, PhD Jun Kobayashi MD, PhD Kalpana Poudel-Tandukar PhD, MPH |
| author_sort | Krishna C. Poudel PhD, MHSc |
| collection | DOAJ |
| description | Background: Previous research has studied the rate of hepatitis C virus (HCV) coinfection among HIV-positive people regardless of their antiretroviral therapy (ART) status. Our objectives were to measure the seroprevalence of HCV both in HIV-positive people receiving ART and in those not receiving ART and to describe the characteristics of coinfected people in the Kathmandu Valley, Nepal. Methods: We conducted a cross-sectional survey of 319 HIV-positive people residing in the Kathmandu Valley, Nepal. We screened the participants’ serum samples for HCV antibodies using the Latex Photometric Immunoassay based on third-generation assay. Results: A total of 138 (43.3%) participants were HCV positive. The prevalence of HCV coinfection was 96.2% (125 of 130) among participants with lifetime injection drug use (IDU). Among participants not receiving ART, the coinfection rate was 58.1% (50 of 86) compared with 37.8% (88 of 233) among those receiving ART. In multivariable analysis, participants who reported lifetime IDU and were current smokers were more likely to have HCV coinfection. The adjusted odds ratio (AOR) of HCV coinfection for ART was decreased, although it was not statistically significant (AOR = 0.45; 95% confidence interval = 0.13-1.48). Conclusion: The high prevalence of HCV coinfection among both individuals receiving ART and those not receiving ART suggests that screening for HCV among HIV-positive people would be useful, in particular, for those with lifetime IDU and soon after their HIV diagnosis. |
| first_indexed | 2024-12-10T08:55:50Z |
| format | Article |
| id | doaj.art-2ea80b2d1be44ee987031f54a4ce4746 |
| institution | Directory Open Access Journal |
| issn | 2325-9574 2325-9582 |
| language | English |
| last_indexed | 2024-12-10T08:55:50Z |
| publishDate | 2014-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-2ea80b2d1be44ee987031f54a4ce47462022-12-22T01:55:26ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822014-05-011310.1177/2325957413500989Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, NepalKrishna C. Poudel PhD, MHSc0Paula H. Palmer PhD1Masamine Jimba MD2Tetsuya Mizoue MD, PhD3Jun Kobayashi MD, PhD4Kalpana Poudel-Tandukar PhD, MPH5 Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA School of Community and Global Health, Claremont Graduate University, Claremont, CA, USA Department of Community and Global Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan Department of Global Health, School of Health Sciences, University of the Ryukyus, Okinawa, Japan Waseda Institute for Advanced Study, Waseda University, Tokyo, JapanBackground: Previous research has studied the rate of hepatitis C virus (HCV) coinfection among HIV-positive people regardless of their antiretroviral therapy (ART) status. Our objectives were to measure the seroprevalence of HCV both in HIV-positive people receiving ART and in those not receiving ART and to describe the characteristics of coinfected people in the Kathmandu Valley, Nepal. Methods: We conducted a cross-sectional survey of 319 HIV-positive people residing in the Kathmandu Valley, Nepal. We screened the participants’ serum samples for HCV antibodies using the Latex Photometric Immunoassay based on third-generation assay. Results: A total of 138 (43.3%) participants were HCV positive. The prevalence of HCV coinfection was 96.2% (125 of 130) among participants with lifetime injection drug use (IDU). Among participants not receiving ART, the coinfection rate was 58.1% (50 of 86) compared with 37.8% (88 of 233) among those receiving ART. In multivariable analysis, participants who reported lifetime IDU and were current smokers were more likely to have HCV coinfection. The adjusted odds ratio (AOR) of HCV coinfection for ART was decreased, although it was not statistically significant (AOR = 0.45; 95% confidence interval = 0.13-1.48). Conclusion: The high prevalence of HCV coinfection among both individuals receiving ART and those not receiving ART suggests that screening for HCV among HIV-positive people would be useful, in particular, for those with lifetime IDU and soon after their HIV diagnosis.https://doi.org/10.1177/2325957413500989 |
| spellingShingle | Krishna C. Poudel PhD, MHSc Paula H. Palmer PhD Masamine Jimba MD Tetsuya Mizoue MD, PhD Jun Kobayashi MD, PhD Kalpana Poudel-Tandukar PhD, MPH Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal Journal of the International Association of Providers of AIDS Care |
| title | Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal |
| title_full | Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal |
| title_fullStr | Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal |
| title_full_unstemmed | Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal |
| title_short | Coinfection with Hepatitis C Virus among HIV-Positive People in the Kathmandu Valley, Nepal |
| title_sort | coinfection with hepatitis c virus among hiv positive people in the kathmandu valley nepal |
| url | https://doi.org/10.1177/2325957413500989 |
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