The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System
Certain strains of Staphylococcus aureus produce a toxin which cause epidermal exfoliation within 18 hours after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). In the present studies a modifi...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
1976-07-01
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| Series: | Acta Medica Iranica |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/11448.pdf&manuscript_id=11448 |
| _version_ | 1819012851186008064 |
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| author | MASSOUD KEYHANI |
| author_facet | MASSOUD KEYHANI |
| author_sort | MASSOUD KEYHANI |
| collection | DOAJ |
| description | Certain strains of Staphylococcus aureus produce a toxin which cause epidermal exfoliation within 18 hours after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). In the present studies a modified assay system has been developed for detection of exfoliativeactivity in toxin negative strains as determined by standa rd method of Melish and Glasgow. If extracellular supernatant material from naturally occuring ET negative st rains was concentrated 20 fold and inoculated into newborn mice, exfoliative toxin act ivity could be detected, |
| first_indexed | 2024-12-21T01:50:37Z |
| format | Article |
| id | doaj.art-2ea96d4b63b74a85b1ad47981fd3b40e |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-21T01:50:37Z |
| publishDate | 1976-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-2ea96d4b63b74a85b1ad47981fd3b40e2022-12-21T19:19:54ZengTehran University of Medical SciencesActa Medica Iranica0044-60251976-07-01XIX4752The Staphy lococcal Exfoliative Toxin Development of a Modified Assay SystemMASSOUD KEYHANICertain strains of Staphylococcus aureus produce a toxin which cause epidermal exfoliation within 18 hours after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). In the present studies a modified assay system has been developed for detection of exfoliativeactivity in toxin negative strains as determined by standa rd method of Melish and Glasgow. If extracellular supernatant material from naturally occuring ET negative st rains was concentrated 20 fold and inoculated into newborn mice, exfoliative toxin act ivity could be detected,http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/11448.pdf&manuscript_id=11448 |
| spellingShingle | MASSOUD KEYHANI The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System Acta Medica Iranica |
| title | The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System |
| title_full | The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System |
| title_fullStr | The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System |
| title_full_unstemmed | The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System |
| title_short | The Staphy lococcal Exfoliative Toxin Development of a Modified Assay System |
| title_sort | staphy lococcal exfoliative toxin development of a modified assay system |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/11448.pdf&manuscript_id=11448 |
| work_keys_str_mv | AT massoudkeyhani thestaphylococcalexfoliativetoxindevelopmentofamodifiedassaysystem AT massoudkeyhani staphylococcalexfoliativetoxindevelopmentofamodifiedassaysystem |