Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection

Single-cell analysis of graft-infiltrating host cells identifies caspase-1 as a potential therapeutic target for heart transplant rejection

AimsUnderstanding the cellular mechanisms underlying early allograft rejection is crucial for the development of effective immunosuppressant strategies. This study aims to investigate the cellular composition of graft-infiltrating cells during the early rejection stage at a single-cell level and ide...

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Bibliographic Details
Main Authors: Zhichao Wu, Jialiang Liang, Shuoji Zhu, Nanbo Liu, Mingyi Zhao, Fei Xiao, Guanhua Li, Changjiang Yu, Chengyu Jin, Jinshan Ma, Tucheng Sun, Ping Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
single cell RNA and transcriptome sequencing
mouse heart transplantation model
immune infifiltration landscape
interferon signaling
inflammasome
allograft rejection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251028/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251028/full

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