Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study
Background Plasma S100A1 protein is a novel inflammatory biomarker associated with acute myocardial infarction and neurodegenerative disease’s pathophysiological mechanisms. This study aimed to determine the levels of this protein in patients with acute ischemic stroke early in the disease progressi...
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PeerJ Inc.
2023-01-01
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| Online Access: | https://peerj.com/articles/14440.pdf |
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| author | Guo Hong Tingting Li Haina Zhao Zhaohao Zeng Jinglei Zhai Xiaobo Li Xiaoguang Luo |
| author_facet | Guo Hong Tingting Li Haina Zhao Zhaohao Zeng Jinglei Zhai Xiaobo Li Xiaoguang Luo |
| author_sort | Guo Hong |
| collection | DOAJ |
| description | Background Plasma S100A1 protein is a novel inflammatory biomarker associated with acute myocardial infarction and neurodegenerative disease’s pathophysiological mechanisms. This study aimed to determine the levels of this protein in patients with acute ischemic stroke early in the disease progression and to investigate its role in the pathogenesis of acute ischemic stroke. Methods A total of 192 participants from hospital stroke centers were collected for the study. Clinically pertinent data were recorded. The volume of the cerebral infarction was calculated according to the Pullicino formula. Multivariate logistic regression analysis was used to select independent influences. ROC curve was used to analyze the diagnostic value of AIS and TIA. The correlation between S100A1, NF-κB p65, and IL-6 levels and cerebral infarction volume was detected by Pearson correlation analysis. Results There were statistically significant differences in S100A1, NF-κB p65, and IL-6 among the AIS,TIA, and PE groups (S100A1, [230.96 ± 39.37] vs [185.85 ± 43.24] vs [181.47 ± 27.39], P < 0.001; NF-κB p65, [3.99 ± 0.65] vs [3.58 ± 0.74] vs [3.51 ± 0.99], P = 0.001; IL-6, [13.32 ± 1.57] vs [11.61 ± 1.67] vs [11.42 ± 2.34], P < 0.001). Multivariate logistic regression analysis showed that S100A1 might be an independent predictive factor for the diagnosis of disease (P < 0.001). The AUC of S100A1 for diagnosis of AIS was 0.818 (P < 0.001, 95% CI [0.749–0.887], cut off 181.03, Jmax 0.578, Se 95.0%, Sp 62.7%). The AUC of S100A1 for diagnosis of TIA was 0.720 (P = 0.001, 95% CI [0.592–0.848], cut off 150.14, Jmax 0.442, Se 50.0%, Sp 94.2%). There were statistically significant differences in S100A1, NF-κB p65, and IL-6 among the SCI,MCI, and LCI groups (S100A1, [223.98 ± 40.21] vs [225.42 ± 30.92] vs [254.25 ± 37.07], P = 0.001; NF-κB p65, [3.88 ± 0.66] vs [3.85 ± 0.64] vs [4.41 ± 0.45], P < 0.001; IL-6, [13.27 ± 1.65] vs [12.77 ± 1.31] vs [14.00 ± 1.40], P = 0.007). Plasma S100A1, NF-κB p65, and IL-6 were significantly different from cerebral infarction volume (S100A1, r = 0.259, P = 0.002; NF-κB p65, r = 0.316, P < 0.001; IL-6, r = 0.177, P = 0.036). There was a positive correlation between plasma S100A1 and IL-6 with statistical significance (R = 0.353, P < 0.001). There was no significant positive correlation between plasma S100A1 and NF-κB p65 (R < 0.3), but there was statistical significance (R = 0.290, P < 0.001). There was a positive correlation between IL-6 and NF-κB p65 with statistical significance (R = 0.313, P < 0.001). Conclusion S100A1 might have a better diagnostic efficacy for AIS and TIA. S100A1 was associated with infarct volume in AIS, and its level reflected the severity of acute cerebral infarction to a certain extent. There was a correlation between S100A1 and IL-6 and NF-κB p65, and it was reasonable to speculate that this protein might mediate the inflammatory response through the NF-κB pathway during the pathophysiology of AIS. |
| first_indexed | 2024-03-09T07:52:25Z |
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| id | doaj.art-2ea99469d5624e55bfe8d267abc67e68 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T07:52:25Z |
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| spelling | doaj.art-2ea99469d5624e55bfe8d267abc67e682023-12-03T01:27:37ZengPeerJ Inc.PeerJ2167-83592023-01-0111e1444010.7717/peerj.14440Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational studyGuo Hong0Tingting Li1Haina Zhao2Zhaohao Zeng3Jinglei Zhai4Xiaobo Li5Xiaoguang Luo6Department of Neurology, Second Clinical Medical College of Jinan University, Shenzhen, ChinaDepartment of Neurology, Yizheng People’s Hospital affiliated to Yangzhou University, Yangzhou, ChinaDepartment of Neurology, Institutes of Brain Science, Jiangsu Subei People’s Hospital affiliated to Yangzhou University, Yangzhou, ChinaDepartment of Neurology, Second Clinical Medical College of Jinan University, Shenzhen, ChinaSchool of Medicine, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Neurology, Institutes of Brain Science, Jiangsu Subei People’s Hospital affiliated to Yangzhou University, Yangzhou, ChinaDepartment of Neurology, Second Clinical Medical College of Jinan University, Shenzhen, ChinaBackground Plasma S100A1 protein is a novel inflammatory biomarker associated with acute myocardial infarction and neurodegenerative disease’s pathophysiological mechanisms. This study aimed to determine the levels of this protein in patients with acute ischemic stroke early in the disease progression and to investigate its role in the pathogenesis of acute ischemic stroke. Methods A total of 192 participants from hospital stroke centers were collected for the study. Clinically pertinent data were recorded. The volume of the cerebral infarction was calculated according to the Pullicino formula. Multivariate logistic regression analysis was used to select independent influences. ROC curve was used to analyze the diagnostic value of AIS and TIA. The correlation between S100A1, NF-κB p65, and IL-6 levels and cerebral infarction volume was detected by Pearson correlation analysis. Results There were statistically significant differences in S100A1, NF-κB p65, and IL-6 among the AIS,TIA, and PE groups (S100A1, [230.96 ± 39.37] vs [185.85 ± 43.24] vs [181.47 ± 27.39], P < 0.001; NF-κB p65, [3.99 ± 0.65] vs [3.58 ± 0.74] vs [3.51 ± 0.99], P = 0.001; IL-6, [13.32 ± 1.57] vs [11.61 ± 1.67] vs [11.42 ± 2.34], P < 0.001). Multivariate logistic regression analysis showed that S100A1 might be an independent predictive factor for the diagnosis of disease (P < 0.001). The AUC of S100A1 for diagnosis of AIS was 0.818 (P < 0.001, 95% CI [0.749–0.887], cut off 181.03, Jmax 0.578, Se 95.0%, Sp 62.7%). The AUC of S100A1 for diagnosis of TIA was 0.720 (P = 0.001, 95% CI [0.592–0.848], cut off 150.14, Jmax 0.442, Se 50.0%, Sp 94.2%). There were statistically significant differences in S100A1, NF-κB p65, and IL-6 among the SCI,MCI, and LCI groups (S100A1, [223.98 ± 40.21] vs [225.42 ± 30.92] vs [254.25 ± 37.07], P = 0.001; NF-κB p65, [3.88 ± 0.66] vs [3.85 ± 0.64] vs [4.41 ± 0.45], P < 0.001; IL-6, [13.27 ± 1.65] vs [12.77 ± 1.31] vs [14.00 ± 1.40], P = 0.007). Plasma S100A1, NF-κB p65, and IL-6 were significantly different from cerebral infarction volume (S100A1, r = 0.259, P = 0.002; NF-κB p65, r = 0.316, P < 0.001; IL-6, r = 0.177, P = 0.036). There was a positive correlation between plasma S100A1 and IL-6 with statistical significance (R = 0.353, P < 0.001). There was no significant positive correlation between plasma S100A1 and NF-κB p65 (R < 0.3), but there was statistical significance (R = 0.290, P < 0.001). There was a positive correlation between IL-6 and NF-κB p65 with statistical significance (R = 0.313, P < 0.001). Conclusion S100A1 might have a better diagnostic efficacy for AIS and TIA. S100A1 was associated with infarct volume in AIS, and its level reflected the severity of acute cerebral infarction to a certain extent. There was a correlation between S100A1 and IL-6 and NF-κB p65, and it was reasonable to speculate that this protein might mediate the inflammatory response through the NF-κB pathway during the pathophysiology of AIS.https://peerj.com/articles/14440.pdfS100A1 calcium-binding proteinNuclear transcription factor κB phosphorylation 65Interleukin 6Acute ischemic strokeCerebral infarctionMechanism |
| spellingShingle | Guo Hong Tingting Li Haina Zhao Zhaohao Zeng Jinglei Zhai Xiaobo Li Xiaoguang Luo Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study PeerJ S100A1 calcium-binding protein Nuclear transcription factor κB phosphorylation 65 Interleukin 6 Acute ischemic stroke Cerebral infarction Mechanism |
| title | Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study |
| title_full | Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study |
| title_fullStr | Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study |
| title_full_unstemmed | Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study |
| title_short | Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study |
| title_sort | diagnostic value and mechanism of plasma s100a1 protein in acute ischemic stroke a prospective and observational study |
| topic | S100A1 calcium-binding protein Nuclear transcription factor κB phosphorylation 65 Interleukin 6 Acute ischemic stroke Cerebral infarction Mechanism |
| url | https://peerj.com/articles/14440.pdf |
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