Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes
Abstract In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized medicine requires the identification of proteins that are expressed by i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Clinical Proteomics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12014-018-9206-0 |
| _version_ | 1811211614515363840 |
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| author | Yvonne S. Ziegler James J. Moresco Patricia G. Tu John R. Yates Ann M. Nardulli |
| author_facet | Yvonne S. Ziegler James J. Moresco Patricia G. Tu John R. Yates Ann M. Nardulli |
| author_sort | Yvonne S. Ziegler |
| collection | DOAJ |
| description | Abstract In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized medicine requires the identification of proteins that are expressed by individual tumors. Herein, we reveal the identity of plasma membrane proteins that are overexpressed in estrogen receptor α-positive, HER2-positive, and triple negative breast cancer cells. The proteins we identified are involved in maintaining protein structure, intracellular homeostasis, and cellular architecture; enhancing cell proliferation and invasion; and influencing cell migration. These proteins may be useful for breast cancer detection and/or treatment. |
| first_indexed | 2024-04-12T05:15:40Z |
| format | Article |
| id | doaj.art-2eadd35956b7404e82fafab3ae27578a |
| institution | Directory Open Access Journal |
| issn | 1542-6416 1559-0275 |
| language | English |
| last_indexed | 2024-04-12T05:15:40Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Proteomics |
| spelling | doaj.art-2eadd35956b7404e82fafab3ae27578a2022-12-22T03:46:37ZengBMCClinical Proteomics1542-64161559-02752018-09-011511910.1186/s12014-018-9206-0Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypesYvonne S. Ziegler0James J. Moresco1Patricia G. Tu2John R. Yates3Ann M. Nardulli4Department of Molecular and Integrative Physiology, University of Illinois at Urbana-ChampaignDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-ChampaignAbstract In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized medicine requires the identification of proteins that are expressed by individual tumors. Herein, we reveal the identity of plasma membrane proteins that are overexpressed in estrogen receptor α-positive, HER2-positive, and triple negative breast cancer cells. The proteins we identified are involved in maintaining protein structure, intracellular homeostasis, and cellular architecture; enhancing cell proliferation and invasion; and influencing cell migration. These proteins may be useful for breast cancer detection and/or treatment.http://link.springer.com/article/10.1186/s12014-018-9206-0Individualized medicinePlasma membrane proteinsProteomic analysisEstrogen receptor α-positive breast cancerHER2-positive breast cancerTriple negative breast cancer |
| spellingShingle | Yvonne S. Ziegler James J. Moresco Patricia G. Tu John R. Yates Ann M. Nardulli Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes Clinical Proteomics Individualized medicine Plasma membrane proteins Proteomic analysis Estrogen receptor α-positive breast cancer HER2-positive breast cancer Triple negative breast cancer |
| title | Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| title_full | Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| title_fullStr | Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| title_full_unstemmed | Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| title_short | Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| title_sort | proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes |
| topic | Individualized medicine Plasma membrane proteins Proteomic analysis Estrogen receptor α-positive breast cancer HER2-positive breast cancer Triple negative breast cancer |
| url | http://link.springer.com/article/10.1186/s12014-018-9206-0 |
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