Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module....
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25464-z |
| _version_ | 1819198461451436032 |
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| author | Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert |
| author_facet | Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert |
| author_sort | Markus Maerker |
| collection | DOAJ |
| description | The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module. |
| first_indexed | 2024-12-23T03:00:49Z |
| format | Article |
| id | doaj.art-2eb07da85f2e46aaa1d04d13bd6e2bee |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T03:00:49Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2eb07da85f2e46aaa1d04d13bd6e2bee2022-12-21T18:02:26ZengNature PortfolioNature Communications2041-17232021-09-0112111510.1038/s41467-021-25464-zBicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5Markus Maerker0Maike Getwan1Megan E. Dowdle2Jason C. McSheene3Vanessa Gonzalez4José L. Pelliccia5Danielle S. Hamilton6Valeria Yartseva7Charles Vejnar8Melanie Tingler9Katsura Minegishi10Philipp Vick11Antonio J. Giraldez12Hiroshi Hamada13Rebecca D. Burdine14Michael D. Sheets15Martin Blum16Axel Schweickert17University of Hohenheim, Institute of Biology, Department of ZoologyUniversity of Zurich, Institute of AnatomyDepartment of Biomolecular Chemistry, University of WisconsinDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Genetics, Yale University School of MedicineDepartment of Genetics, Yale University School of MedicineUniversity of Hohenheim, Institute of Biology, Department of ZoologyLaboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics ResearchUniversity of Hohenheim, Institute of Biology, Department of ZoologyDepartment of Genetics, Yale University School of MedicineLaboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics ResearchDepartment of Molecular Biology, Princeton UniversityDepartment of Biomolecular Chemistry, University of WisconsinUniversity of Hohenheim, Institute of Biology, Department of ZoologyUniversity of Hohenheim, Institute of Biology, Department of ZoologyThe authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.https://doi.org/10.1038/s41467-021-25464-z |
| spellingShingle | Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 Nature Communications |
| title | Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 |
| title_full | Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 |
| title_fullStr | Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 |
| title_full_unstemmed | Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 |
| title_short | Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 |
| title_sort | bicc1 and dicer regulate left right patterning through post transcriptional control of the nodal inhibitor dand5 |
| url | https://doi.org/10.1038/s41467-021-25464-z |
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