The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.664872/full |
| _version_ | 1818690708808138752 |
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| author | Sonia Jimeno Sonia Jimeno Fernando R. Balestra Fernando R. Balestra Pablo Huertas Pablo Huertas |
| author_facet | Sonia Jimeno Sonia Jimeno Fernando R. Balestra Fernando R. Balestra Pablo Huertas Pablo Huertas |
| author_sort | Sonia Jimeno |
| collection | DOAJ |
| description | The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field. |
| first_indexed | 2024-12-17T12:30:18Z |
| format | Article |
| id | doaj.art-2eb1557ff80c43ffb5f2a1225e749225 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-17T12:30:18Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-2eb1557ff80c43ffb5f2a1225e7492252022-12-21T21:48:36ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-04-01810.3389/fmolb.2021.664872664872The Emerging Role of RNA Modifications in DNA Double-Strand Break RepairSonia Jimeno0Sonia Jimeno1Fernando R. Balestra2Fernando R. Balestra3Pablo Huertas4Pablo Huertas5Departamento de Genética, Universidad de Sevilla, Seville, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, SpainDepartamento de Genética, Universidad de Sevilla, Seville, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, SpainDepartamento de Genética, Universidad de Sevilla, Seville, SpainCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, SpainThe correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.https://www.frontiersin.org/articles/10.3389/fmolb.2021.664872/fullRNA modificationDNA repairhomologous recombinationDNA resectionR-loop |
| spellingShingle | Sonia Jimeno Sonia Jimeno Fernando R. Balestra Fernando R. Balestra Pablo Huertas Pablo Huertas The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair Frontiers in Molecular Biosciences RNA modification DNA repair homologous recombination DNA resection R-loop |
| title | The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair |
| title_full | The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair |
| title_fullStr | The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair |
| title_full_unstemmed | The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair |
| title_short | The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair |
| title_sort | emerging role of rna modifications in dna double strand break repair |
| topic | RNA modification DNA repair homologous recombination DNA resection R-loop |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.664872/full |
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