A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet cl...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=1;spage=93;epage=97;aulast=Suresh |
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| author | Sangeetha Suresh Bijayraj Rajanbabu Vimal Mavila Veetil Abeed Hussain Jaseena Nadu Veetil |
| author_facet | Sangeetha Suresh Bijayraj Rajanbabu Vimal Mavila Veetil Abeed Hussain Jaseena Nadu Veetil |
| author_sort | Sangeetha Suresh |
| collection | DOAJ |
| description | Introduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Aims and Objectives: The aim and objective of this study is to determine the prevalence of undetected diabetes, dyslipidemia, and IR in subjects with NAFLD. Materials and Methods: In apparently healthy 100 subjects, with ultrasound diagnosis of fatty liver, fasting and postprandial blood sugar levels, fasting insulin levels, and fasting lipid profile were checked. IR value was estimated using homeostatic model assessment-IR formula. Appropriate statistical methods were adopted to analyze the data. Results: A total of 66 subjects out of the 100 had IR. It was noted that IR significantly correlated with raised fasting blood sugar and fasting plasma insulin values. There was no significant correlation between IR and lipid profile values. Conclusion: The chance of developing NAFLD was high if the subjects are having IR, or vice versa. There was an increased prevalence of prediabetes and diabetes in the subjects with NAFLD. Waist circumference, rather than body mass index, was found to be a strong predictor of central adiposity and IR. |
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| format | Article |
| id | doaj.art-2eb29e7e53eb4934aadcef035bfb2e00 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-21T02:22:31Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-2eb29e7e53eb4934aadcef035bfb2e002022-12-21T19:19:05ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632018-01-0171939710.4103/jfmpc.jfmpc_352_16A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver diseaseSangeetha SureshBijayraj RajanbabuVimal Mavila VeetilAbeed HussainJaseena Nadu VeetilIntroduction: Nonalcoholic fatty liver disease (NAFLD) is a hepatic disorder that develops in the absence of alcohol intake. Obesity and diabetes are considered risk factors for the development of fatty liver; however, whether fatty liver is the cause or consequence of these conditions is not yet clear. Insulin resistance (IR) is found to be a common risk factor for the development of diabetes, obesity and fatty liver. Aims and Objectives: The aim and objective of this study is to determine the prevalence of undetected diabetes, dyslipidemia, and IR in subjects with NAFLD. Materials and Methods: In apparently healthy 100 subjects, with ultrasound diagnosis of fatty liver, fasting and postprandial blood sugar levels, fasting insulin levels, and fasting lipid profile were checked. IR value was estimated using homeostatic model assessment-IR formula. Appropriate statistical methods were adopted to analyze the data. Results: A total of 66 subjects out of the 100 had IR. It was noted that IR significantly correlated with raised fasting blood sugar and fasting plasma insulin values. There was no significant correlation between IR and lipid profile values. Conclusion: The chance of developing NAFLD was high if the subjects are having IR, or vice versa. There was an increased prevalence of prediabetes and diabetes in the subjects with NAFLD. Waist circumference, rather than body mass index, was found to be a strong predictor of central adiposity and IR.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=1;spage=93;epage=97;aulast=SureshDyslipidemiainsulin resistancenonalcoholic fatty liver diseaseobesitytype 2 diabetes mellitus |
| spellingShingle | Sangeetha Suresh Bijayraj Rajanbabu Vimal Mavila Veetil Abeed Hussain Jaseena Nadu Veetil A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease Journal of Family Medicine and Primary Care Dyslipidemia insulin resistance nonalcoholic fatty liver disease obesity type 2 diabetes mellitus |
| title | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| title_full | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| title_fullStr | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| title_full_unstemmed | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| title_short | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| title_sort | study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease |
| topic | Dyslipidemia insulin resistance nonalcoholic fatty liver disease obesity type 2 diabetes mellitus |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2018;volume=7;issue=1;spage=93;epage=97;aulast=Suresh |
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