The distribution and 'in vivo' phase variation status of haemoglobin receptors in invasive meningococcal serogroup B disease: genotypic and phenotypic analysis.

The distribution and 'in vivo' phase variation status of haemoglobin receptors in invasive meningococcal serogroup B disease: genotypic and phenotypic analysis.

Two haemoglobin-binding proteins, HmbR and HpuAB, contribute to iron acquisition by Neisseria meningitidis. These receptors are subject to high frequency, reversible switches in gene expression--phase variation (PV)--due to mutations in homopolymeric (poly-G) repeats present in the open reading fram...

Full description

Bibliographic Details
Main Authors: Jay Lucidarme, Jamie Findlow, Hannah Chan, Ian M Feavers, Stephen J Gray, Edward B Kaczmarski, Julian Parkhill, Xilian Bai, Ray Borrow, Christopher D Bayliss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3786947?pdf=render

Similar Items

Similar Items