Numerical modelling of the dissolution of drug nanocrystals and its application to industrial product development

The apparent solubility of drug nanocrystals in equilibrium was experimentally determined for a drug-stabilizer system with different particle size distributions. True supersaturation was identified for ultrafine drug nanocrystals with an almost 2-fold increase compared to the thermodynamic solubil...

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Hlavní autoři: Bastian Bonhoeffer, Andreas Kordikowski, Edgar John, Michael Juhnke
Médium: Článek
Jazyk:English
Vydáno: International Association of Physical Chemists (IAPC) 2022-08-01
Edice:ADMET and DMPK
On-line přístup:https://pub.iapchem.org/ojs/index.php/admet/article/view/1437