Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy
Background and Aim: Extracellular vesicles (EVs) are key players in cellular communication and signaling in the health status and diseases. EVs have rather small size and long half-life upon secretion into circulation. This long half-life along with their immune privileged profile and the ability to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2023-10-01
|
| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-7635-en.pdf |
| _version_ | 1797285586089803776 |
|---|---|
| author | jamal majidpoor fardin fathi Keywan Mortezaee |
| author_facet | jamal majidpoor fardin fathi Keywan Mortezaee |
| author_sort | jamal majidpoor |
| collection | DOAJ |
| description | Background and Aim: Extracellular vesicles (EVs) are key players in cellular communication and signaling in the health status and diseases. EVs have rather small size and long half-life upon secretion into circulation. This long half-life along with their immune privileged profile and the ability to carry biotherapeutics to the target cells have made EVs an issue of prominent current interest among scientists as an alternative schedule in cancer therapy.
Materials and Methods: PubMed and Google scholar were searched for relevant articles from journals with high impact factor. Among 400 articles found, 40 articles met the criteria for interpretation and were selected for descriptive review. Original and review articles published in the last ten years were used in this study.
Results: Tumor-derived EVs can be targeted for reducing cancer cell survival and increasing their apoptosis. They are also applicable for drug delivery to primary or metastatic tumors. An effective approach is to load nanoparticles into EVs for targeting a specific cell type in tumor ecosystem. Their application in nano delivery systems for cancer therapy has been the focus of attention.
Conclusion: The current studies have focused on the possibility of using EVs as biomarkers in several diseases, as targets to be removed for recovery of the patient health, and as vehicles for immunotherapy. In this review article, we discussed the importance of EV suppression or EV-based strategy for targeting solid cancers |
| first_indexed | 2024-03-07T18:05:19Z |
| format | Article |
| id | doaj.art-2eb42826e18a4589b7f8271a9c57214a |
| institution | Directory Open Access Journal |
| issn | 1560-652X 2345-4040 |
| language | fas |
| last_indexed | 2024-03-07T18:05:19Z |
| publishDate | 2023-10-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-2eb42826e18a4589b7f8271a9c57214a2024-03-02T09:28:13ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402023-10-01284160173Strategies for Application of Extracellular Vesicles in Solid Cancer Therapyjamal majidpoor0fardin fathi1Keywan Mortezaee2 Department of Anatomy, School of Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Background and Aim: Extracellular vesicles (EVs) are key players in cellular communication and signaling in the health status and diseases. EVs have rather small size and long half-life upon secretion into circulation. This long half-life along with their immune privileged profile and the ability to carry biotherapeutics to the target cells have made EVs an issue of prominent current interest among scientists as an alternative schedule in cancer therapy. Materials and Methods: PubMed and Google scholar were searched for relevant articles from journals with high impact factor. Among 400 articles found, 40 articles met the criteria for interpretation and were selected for descriptive review. Original and review articles published in the last ten years were used in this study. Results: Tumor-derived EVs can be targeted for reducing cancer cell survival and increasing their apoptosis. They are also applicable for drug delivery to primary or metastatic tumors. An effective approach is to load nanoparticles into EVs for targeting a specific cell type in tumor ecosystem. Their application in nano delivery systems for cancer therapy has been the focus of attention. Conclusion: The current studies have focused on the possibility of using EVs as biomarkers in several diseases, as targets to be removed for recovery of the patient health, and as vehicles for immunotherapy. In this review article, we discussed the importance of EV suppression or EV-based strategy for targeting solid cancershttp://sjku.muk.ac.ir/article-1-7635-en.pdfextracellular vesicle (ev)exosomecancertherapy |
| spellingShingle | jamal majidpoor fardin fathi Keywan Mortezaee Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy مجله علمی دانشگاه علوم پزشکی کردستان extracellular vesicle (ev) exosome cancer therapy |
| title | Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy |
| title_full | Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy |
| title_fullStr | Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy |
| title_full_unstemmed | Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy |
| title_short | Strategies for Application of Extracellular Vesicles in Solid Cancer Therapy |
| title_sort | strategies for application of extracellular vesicles in solid cancer therapy |
| topic | extracellular vesicle (ev) exosome cancer therapy |
| url | http://sjku.muk.ac.ir/article-1-7635-en.pdf |
| work_keys_str_mv | AT jamalmajidpoor strategiesforapplicationofextracellularvesiclesinsolidcancertherapy AT fardinfathi strategiesforapplicationofextracellularvesiclesinsolidcancertherapy AT keywanmortezaee strategiesforapplicationofextracellularvesiclesinsolidcancertherapy |