The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury
Aim: This study was designed to evaluate the efficacy of dexmedetomidine (DEX) as a hypotensive agent in comparison to nitroglycerin (NTG) in posterior fixation surgery for traumatic spine injury. Materials and Methods: Forty patients ASA I or II aged 18-65 years scheduled for posterior fixation su...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
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| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=2;spage=203;epage=207;aulast=Jamaliya |
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| author | Ramila H Jamaliya Rajesh Chinnachamy Jyotsna Maliwad Varun P Deshmukh Bharat J Shah Indu A Chadha |
| author_facet | Ramila H Jamaliya Rajesh Chinnachamy Jyotsna Maliwad Varun P Deshmukh Bharat J Shah Indu A Chadha |
| author_sort | Ramila H Jamaliya |
| collection | DOAJ |
| description | Aim: This study was designed to evaluate the efficacy of dexmedetomidine (DEX) as a hypotensive agent in comparison to nitroglycerin (NTG) in posterior fixation surgery for traumatic spine injury.
Materials and Methods: Forty patients ASA I or II aged 18-65 years scheduled for posterior fixation surgery were randomly assigned to receive either DEX 1 μg/kg over 10 min before induction of anesthesia followed by 0.2-0.7 μg/kg/h infusion during maintenance in DEX group or NTG 3-5 μg/kg/min infusion after induction of anesthesia in NTG group to maintain mean arterial blood pressure (MAP) between 65 and 70 mmHg. The two groups were compared for achievement of target MAP, intraoperative blood loss, and reversibility of hypotensive state.Student′s t-test was used for continuous variables and chi-square test for categorical variables. P-value < 0.05 was considered significant.
Results: Patients in DEX group achieved the target MAP with better heart rate (HR) control, as compared to NTG group during the period of observation. The blood loss was significantly lesser in the DEX group (422.11 ± 149.34 ml) than the NTG group (564.51 ± 160.88 ml), P = 0.01. The time to hypotension reversal in NTG group (5.63 ± 1.93 min) was lesser compared to DEX group (9.15 ± 2.16 min), P = 0.65.
Conclusion: DEX is an effective and safe agent in achieving controlled hypotension in adults undergoing posterior fixation spine surgery. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-21T05:40:32Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-2eb5e950c50f476a844345f3e771de5e2022-12-21T19:14:16ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852014-01-0130220320710.4103/0970-9185.130021The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injuryRamila H JamaliyaRajesh ChinnachamyJyotsna MaliwadVarun P DeshmukhBharat J ShahIndu A ChadhaAim: This study was designed to evaluate the efficacy of dexmedetomidine (DEX) as a hypotensive agent in comparison to nitroglycerin (NTG) in posterior fixation surgery for traumatic spine injury. Materials and Methods: Forty patients ASA I or II aged 18-65 years scheduled for posterior fixation surgery were randomly assigned to receive either DEX 1 μg/kg over 10 min before induction of anesthesia followed by 0.2-0.7 μg/kg/h infusion during maintenance in DEX group or NTG 3-5 μg/kg/min infusion after induction of anesthesia in NTG group to maintain mean arterial blood pressure (MAP) between 65 and 70 mmHg. The two groups were compared for achievement of target MAP, intraoperative blood loss, and reversibility of hypotensive state.Student′s t-test was used for continuous variables and chi-square test for categorical variables. P-value < 0.05 was considered significant. Results: Patients in DEX group achieved the target MAP with better heart rate (HR) control, as compared to NTG group during the period of observation. The blood loss was significantly lesser in the DEX group (422.11 ± 149.34 ml) than the NTG group (564.51 ± 160.88 ml), P = 0.01. The time to hypotension reversal in NTG group (5.63 ± 1.93 min) was lesser compared to DEX group (9.15 ± 2.16 min), P = 0.65. Conclusion: DEX is an effective and safe agent in achieving controlled hypotension in adults undergoing posterior fixation spine surgery.http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=2;spage=203;epage=207;aulast=Jamaliyaα2-agonistcontrolled hypotensiondexmedetomidinespine surgery |
| spellingShingle | Ramila H Jamaliya Rajesh Chinnachamy Jyotsna Maliwad Varun P Deshmukh Bharat J Shah Indu A Chadha The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury Journal of Anaesthesiology Clinical Pharmacology α2-agonist controlled hypotension dexmedetomidine spine surgery |
| title | The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| title_full | The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| title_fullStr | The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| title_full_unstemmed | The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| title_short | The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| title_sort | efficacy and hemodynamic response to dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury |
| topic | α2-agonist controlled hypotension dexmedetomidine spine surgery |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=2;spage=203;epage=207;aulast=Jamaliya |
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