Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus
Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.755729/full |
| _version_ | 1818588026889043968 |
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| author | Verónica Company Ana Moreno-Cerdá Abraham Andreu-Cervera Raquel Murcia-Ramón Francisca Almagro-García Diego Echevarría Salvador Martínez Eduardo Puelles |
| author_facet | Verónica Company Ana Moreno-Cerdá Abraham Andreu-Cervera Raquel Murcia-Ramón Francisca Almagro-García Diego Echevarría Salvador Martínez Eduardo Puelles |
| author_sort | Verónica Company |
| collection | DOAJ |
| description | Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is involved in the limbic system and its malfunction is related with several psychiatric disorders. Our aim is to elucidate the Wnt1 role in the habenula and its main efferent tract, the fasciculus retroflexus, development. In order to achieve these objectives, we analyzed these structures development in a Wnt1 lack of function mouse model. The habenula was generated in our model, but it presented an enlarged volume. This alteration was due to an increment in habenular neuroblasts proliferation rate. The fasciculus retroflexus also presented a wider and disorganized distribution and a disturbed final trajectory toward its target. The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the habenula is Wnt1 independent. Nevertheless, it controls its precursors proliferation rate. Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. The alteration of these areas is responsible for the fasciculus retroflexus axons misroute. |
| first_indexed | 2024-12-16T09:18:13Z |
| format | Article |
| id | doaj.art-2eb6620a7fae409a9d45813d9249f038 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T09:18:13Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2eb6620a7fae409a9d45813d9249f0382022-12-21T22:36:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-10-01910.3389/fcell.2021.755729755729Wnt1 Role in the Development of the Habenula and the Fasciculus RetroflexusVerónica CompanyAna Moreno-CerdáAbraham Andreu-CerveraRaquel Murcia-RamónFrancisca Almagro-GarcíaDiego EchevarríaSalvador MartínezEduardo PuellesWnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is involved in the limbic system and its malfunction is related with several psychiatric disorders. Our aim is to elucidate the Wnt1 role in the habenula and its main efferent tract, the fasciculus retroflexus, development. In order to achieve these objectives, we analyzed these structures development in a Wnt1 lack of function mouse model. The habenula was generated in our model, but it presented an enlarged volume. This alteration was due to an increment in habenular neuroblasts proliferation rate. The fasciculus retroflexus also presented a wider and disorganized distribution and a disturbed final trajectory toward its target. The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the habenula is Wnt1 independent. Nevertheless, it controls its precursors proliferation rate. Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. The alteration of these areas is responsible for the fasciculus retroflexus axons misroute.https://www.frontiersin.org/articles/10.3389/fcell.2021.755729/fullWnt1habenulafasciculus retroflexusproliferationdifferentiation |
| spellingShingle | Verónica Company Ana Moreno-Cerdá Abraham Andreu-Cervera Raquel Murcia-Ramón Francisca Almagro-García Diego Echevarría Salvador Martínez Eduardo Puelles Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus Frontiers in Cell and Developmental Biology Wnt1 habenula fasciculus retroflexus proliferation differentiation |
| title | Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus |
| title_full | Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus |
| title_fullStr | Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus |
| title_full_unstemmed | Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus |
| title_short | Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus |
| title_sort | wnt1 role in the development of the habenula and the fasciculus retroflexus |
| topic | Wnt1 habenula fasciculus retroflexus proliferation differentiation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.755729/full |
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