SFRP5 as a new cardiovascular biological marker: a literature review
Research into new biological markers may help early diagnosis and effective therapy for cardiology patients. The use of biomarkers to evaluate patients has made a major impact in oncology, but is still in its infancy in the cardiology field. Studies on secreted frizzled-related protein 5 (SFRP5) hav...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Concilium Medicum
2023-04-01
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| Series: | КардиоСоматика |
| Subjects: | |
| Online Access: | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/139218/pdf_2 |
| _version_ | 1797846672046292992 |
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| author | Amina M. Alieva Natalia V. Teplova Irina E. Baykova Kira V. Voronkova Lidiya M. Shnakhova Lyudmila M. Makeeva Irina A. Kotikova Igor G. Nikitin |
| author_facet | Amina M. Alieva Natalia V. Teplova Irina E. Baykova Kira V. Voronkova Lidiya M. Shnakhova Lyudmila M. Makeeva Irina A. Kotikova Igor G. Nikitin |
| author_sort | Amina M. Alieva |
| collection | DOAJ |
| description | Research into new biological markers may help early diagnosis and effective therapy for cardiology patients. The use of biomarkers to evaluate patients has made a major impact in oncology, but is still in its infancy in the cardiology field. Studies on secreted frizzled-related protein 5 (SFRP5) have revealed its potential use as a marker of cardiovascular pathology. Preclinical studies have highlighted the important role this protein plays in many biological processes. It reduces the proliferation and migration of cardiac fibroblasts and suppresses the Wnt5A/JNK signaling pathway thus reducing the severity of oxidative stress and inflammation. It normalizes nitric oxide production and has several other effects. However, recent clinical studies of SFRP5 have produced conflicting data. Nevertheless, this protein shows promise as a marker for several metabolic and cardiovascular diseases. Preliminary data also suggest SFRP5 may be a therapeutic target. Further study of SFRP5 and its role in cardiovascular pathology is necessary, and will create new diagnostic and prognostic possibilities for this biological marker. |
| first_indexed | 2024-04-09T17:58:46Z |
| format | Article |
| id | doaj.art-2eb7540240da4319b59b00283bac2022 |
| institution | Directory Open Access Journal |
| issn | 2221-7185 2658-5707 |
| language | English |
| last_indexed | 2024-04-09T17:58:46Z |
| publishDate | 2023-04-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj.art-2eb7540240da4319b59b00283bac20222023-04-14T09:35:07ZengConcilium MedicumКардиоСоматика2221-71852658-57072023-04-0113420621210.17816/CS13921876523SFRP5 as a new cardiovascular biological marker: a literature reviewAmina M. Alieva0https://orcid.org/0000-0001-5416-8579Natalia V. Teplova1https://orcid.org/0000-0002-7181-4680Irina E. Baykova2https://orcid.org/0000-0003-0886-6290Kira V. Voronkova3https://orcid.org/0000-0003-1111-6378Lidiya M. Shnakhova4https://orcid.org/0000-0003-3000-0987Lyudmila M. Makeeva5https://orcid.org/0000-0003-0755-4869Irina A. Kotikova6https://orcid.org/0000-0001-5352-8499Igor G. Nikitin7https://orcid.org/0000-0003-1699-0881Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversitySechenov First Moscow State Medical University (Sechenov Unuiversity)Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityResearch into new biological markers may help early diagnosis and effective therapy for cardiology patients. The use of biomarkers to evaluate patients has made a major impact in oncology, but is still in its infancy in the cardiology field. Studies on secreted frizzled-related protein 5 (SFRP5) have revealed its potential use as a marker of cardiovascular pathology. Preclinical studies have highlighted the important role this protein plays in many biological processes. It reduces the proliferation and migration of cardiac fibroblasts and suppresses the Wnt5A/JNK signaling pathway thus reducing the severity of oxidative stress and inflammation. It normalizes nitric oxide production and has several other effects. However, recent clinical studies of SFRP5 have produced conflicting data. Nevertheless, this protein shows promise as a marker for several metabolic and cardiovascular diseases. Preliminary data also suggest SFRP5 may be a therapeutic target. Further study of SFRP5 and its role in cardiovascular pathology is necessary, and will create new diagnostic and prognostic possibilities for this biological marker.https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/139218/pdf_2biological markercardiovascular diseasesfrp5 |
| spellingShingle | Amina M. Alieva Natalia V. Teplova Irina E. Baykova Kira V. Voronkova Lidiya M. Shnakhova Lyudmila M. Makeeva Irina A. Kotikova Igor G. Nikitin SFRP5 as a new cardiovascular biological marker: a literature review КардиоСоматика biological marker cardiovascular disease sfrp5 |
| title | SFRP5 as a new cardiovascular biological marker: a literature review |
| title_full | SFRP5 as a new cardiovascular biological marker: a literature review |
| title_fullStr | SFRP5 as a new cardiovascular biological marker: a literature review |
| title_full_unstemmed | SFRP5 as a new cardiovascular biological marker: a literature review |
| title_short | SFRP5 as a new cardiovascular biological marker: a literature review |
| title_sort | sfrp5 as a new cardiovascular biological marker a literature review |
| topic | biological marker cardiovascular disease sfrp5 |
| url | https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/139218/pdf_2 |
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