Mutations of RAS genes identified in acute myeloid leukemia affect glycerophospholipid metabolism pathway

Mutations of RAS genes identified in acute myeloid leukemia affect glycerophospholipid metabolism pathway

BackgroundAcute myeloid leukemia (AML) is a malignant disease originating from myeloid hematopoietic stem cells. Recent studies have shown that certain gene mutations promote tumor cell survival and affect the prognosis of patients by affecting metabolic mechanisms in tumor cells. RAS gene mutations...

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Bibliographic Details
Main Authors: Tianqi Liang, Yanxiang Kong, Hongman Xue, Wenqing Wang, Chunmou Li, Chun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
NRAS Q61K
KRAS G12V
glycerophospholipid metabolism
DGKzeta
PLA2G4A
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1280192/full

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