Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis
<b>Aim:</b> There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/10/1875 |
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| author | Aleksandra Klisic Mirjana Bakic Vesna Karanikolic |
| author_facet | Aleksandra Klisic Mirjana Bakic Vesna Karanikolic |
| author_sort | Aleksandra Klisic |
| collection | DOAJ |
| description | <b>Aim:</b> There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive and specific oxidative stress biomarker that could best reflect the existence of one of these disease entities. <b>Methods:</b> Forty patients with PsO and forty patients with AD were consecutively included in this cross-sectional study. Parameters of redox homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) and advanced oxidation protein products (AOPP)] and antioxidants [catalase (CAT) and superoxide dismutase (SOD)] were determined. <b>Results:</b> There was no difference in oxidative stress biomarkers between the PsO and AD group, except for higher CAT activity in the AD group (<i>p</i> < 0.001). Among all examined redox homeostasis biomarkers, ROC analysis showed that only CAT exhibited good diagnostic accuracy (AUC = 0.719) in the discrimination of patients with PsO vs. AD, with 0.436 U/L as the cut-off value of CAT activity. <b>Conclusions:</b> The CAT exhibited good diagnostic accuracy in the discrimination of patients with AD from those with PsO. The obtained results could suggest the importance of the use of antioxidants as a potential therapeutic strategy in the treatment of these two skin inflammatory diseases. |
| first_indexed | 2024-03-10T21:29:09Z |
| format | Article |
| id | doaj.art-2ebb952cbded44f699227eba764f1ded |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T21:29:09Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2ebb952cbded44f699227eba764f1ded2023-11-19T15:28:24ZengMDPI AGAntioxidants2076-39212023-10-011210187510.3390/antiox12101875Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic DermatitisAleksandra Klisic0Mirjana Bakic1Vesna Karanikolic2Faculty of Medicine, University of Montenegro, 81000 Podgorica, MontenegroClinic for Dermatovenerology, Clinical Center of Montenegro, 81000 Podgorica, MontenegroClinic for Skin Diseases of the Clinical Center Nis, School of Medicine, University of Nis, 18000 Nis, Serbia<b>Aim:</b> There are no studies regarding comparative analysis of serum biomarkers of oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the serum redox homeostasis parameters in patients with PsO vs. AD in an attempt to find the sensitive and specific oxidative stress biomarker that could best reflect the existence of one of these disease entities. <b>Methods:</b> Forty patients with PsO and forty patients with AD were consecutively included in this cross-sectional study. Parameters of redox homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) and advanced oxidation protein products (AOPP)] and antioxidants [catalase (CAT) and superoxide dismutase (SOD)] were determined. <b>Results:</b> There was no difference in oxidative stress biomarkers between the PsO and AD group, except for higher CAT activity in the AD group (<i>p</i> < 0.001). Among all examined redox homeostasis biomarkers, ROC analysis showed that only CAT exhibited good diagnostic accuracy (AUC = 0.719) in the discrimination of patients with PsO vs. AD, with 0.436 U/L as the cut-off value of CAT activity. <b>Conclusions:</b> The CAT exhibited good diagnostic accuracy in the discrimination of patients with AD from those with PsO. The obtained results could suggest the importance of the use of antioxidants as a potential therapeutic strategy in the treatment of these two skin inflammatory diseases.https://www.mdpi.com/2076-3921/12/10/1875atopic dermatitisinflammationoxidative stresspsoriasis |
| spellingShingle | Aleksandra Klisic Mirjana Bakic Vesna Karanikolic Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis Antioxidants atopic dermatitis inflammation oxidative stress psoriasis |
| title | Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis |
| title_full | Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis |
| title_fullStr | Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis |
| title_full_unstemmed | Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis |
| title_short | Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis |
| title_sort | comparative analysis of redox homeostasis biomarkers in patients with psoriasis and atopic dermatitis |
| topic | atopic dermatitis inflammation oxidative stress psoriasis |
| url | https://www.mdpi.com/2076-3921/12/10/1875 |
| work_keys_str_mv | AT aleksandraklisic comparativeanalysisofredoxhomeostasisbiomarkersinpatientswithpsoriasisandatopicdermatitis AT mirjanabakic comparativeanalysisofredoxhomeostasisbiomarkersinpatientswithpsoriasisandatopicdermatitis AT vesnakaranikolic comparativeanalysisofredoxhomeostasisbiomarkersinpatientswithpsoriasisandatopicdermatitis |