Does clozapine induce myocarditis, myocardial oxidative stress and DNA damage in rats?

Does clozapine induce myocarditis, myocardial oxidative stress and DNA damage in rats?

Clozapine is an atypical antipsychotic drug selectively effective in the treatment of refractory schizophrenia. However, myocarditis, as a serious cardiotoxic effect, has in several case reports been associated with clozapine therapy. Ani increase in the free radical production and ischemia, probabl...

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Bibliographic Details
Main Authors: Basel A. Abdel-Wahab, Metwally E. Abdalla, Mohamed M. El-khawanki
Format: Article
Language:English
Published: SpringerOpen 2014-09-01
Series:Egyptian Journal of Forensic Sciences
Subjects:
Clozapine
Myocarditis
Oxidative stress
TNF-α
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2090536X14000227

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