Cancer stem cell-derived CHI3L1 activates the MAF/CTLA4 signaling pathway to promote immune escape in triple-negative breast cancer

Cancer stem cell-derived CHI3L1 activates the MAF/CTLA4 signaling pathway to promote immune escape in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) development may be associated with tumor immune escape. This study explores whether the CHI3L1/MAF/CTLA4/S100A4 axis affects immune escape in TNBC through interplay with triple-negative breast cancer stem cells (TN-BCSCs). Objective The aim of...

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Bibliographic Details
Main Authors: Shufeng Ji, Hao Yu, Dan Zhou, Xulong Fan, Yan Duan, Yijiang Tan, Min Lang, Guoli Shao
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
CHI3L1
CTLA4
MAF
S100A4
Triple-negative breast cancer
Cancer stem cells
Online Access:https://doi.org/10.1186/s12967-023-04532-6

Internet

https://doi.org/10.1186/s12967-023-04532-6

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