Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
Abstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-19166-8 |
| _version_ | 1818344899008790528 |
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| author | Cameron A. Stewart Yoav Finer Benjamin D. Hatton |
| author_facet | Cameron A. Stewart Yoav Finer Benjamin D. Hatton |
| author_sort | Cameron A. Stewart |
| collection | DOAJ |
| description | Abstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up. |
| first_indexed | 2024-12-13T16:53:48Z |
| format | Article |
| id | doaj.art-2ebefac9bc1a415ea6d6bfb0390d5c85 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T16:53:48Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2ebefac9bc1a415ea6d6bfb0390d5c852022-12-21T23:37:58ZengNature PortfolioScientific Reports2045-23222018-01-018111210.1038/s41598-018-19166-8Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particlesCameron A. Stewart0Yoav Finer1Benjamin D. Hatton2Institute of Biomaterials and Biomedical Engineering, University of TorontoInstitute of Biomaterials and Biomedical Engineering, University of TorontoInstitute of Biomaterials and Biomedical Engineering, University of TorontoAbstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.https://doi.org/10.1038/s41598-018-19166-8 |
| spellingShingle | Cameron A. Stewart Yoav Finer Benjamin D. Hatton Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles Scientific Reports |
| title | Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles |
| title_full | Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles |
| title_fullStr | Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles |
| title_full_unstemmed | Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles |
| title_short | Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles |
| title_sort | drug self assembly for synthesis of highly loaded antimicrobial drug silica particles |
| url | https://doi.org/10.1038/s41598-018-19166-8 |
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