Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease

Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease

Abstract Background Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In this study we aimed to determine the relationship of the epigenetic reg...

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Main Authors: Ana I. Hernández Cordero, Chen Xi Yang, Xuan Li, Stephen Milne, Virginia Chen, Zsuzsanna Hollander, Raymond Ng, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, John E. Connett, MeiLan K. Han, Fernando J. Martinez, Robert M. Reed, S. F. Paul Man, Janice M. Leung, Don D. Sin
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Respiratory Research
Subjects:
COPD
Telomeres
AECOPD
Epigenetics
DNA methylation
Online Access:https://doi.org/10.1186/s12931-021-01911-9

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