Rational peptide design for regulating liquid–liquid phase separation on the basis of residue–residue contact energy

Rational peptide design for regulating liquid–liquid phase separation on the basis of residue–residue contact energy

Abstract Since liquid–liquid phase separation (LLPS) of proteins is governed by their intrinsically disordered regions (IDRs), it can be controlled by LLPS-regulators that bind to the IDRs. The artificial design of LLPS-regulators based on this mechanism can be leveraged in biological and therapeuti...

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Bibliographic Details
Main Authors: Kiyoto Kamagata, Maulana Ariefai, Hiroto Takahashi, Atsumi Hando, Dwiky Rendra Graha Subekti, Keisuke Ikeda, Atsushi Hirano, Tomoshi Kameda
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17829-1

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https://doi.org/10.1038/s41598-022-17829-1

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