Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder
Abstract Background Methylphenidate (MPH), also called Ritalin, is used to treat attention-deficit hyperactivity disorder (ADHD) patients. With occasional reports of subjects suffering from Methylphenidate use disorder (MPHUD), few studies analyzed the neuropsychological changes in this population....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04187-5 |
| _version_ | 1817999021000622080 |
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| author | Jie Xu Yi Zhang Nan Wang Pei Sun Fuqiang Mao Ti-Fei Yuan |
| author_facet | Jie Xu Yi Zhang Nan Wang Pei Sun Fuqiang Mao Ti-Fei Yuan |
| author_sort | Jie Xu |
| collection | DOAJ |
| description | Abstract Background Methylphenidate (MPH), also called Ritalin, is used to treat attention-deficit hyperactivity disorder (ADHD) patients. With occasional reports of subjects suffering from Methylphenidate use disorder (MPHUD), few studies analyzed the neuropsychological changes in this population. Purpose This study aims to evaluate the clinical outcomes of individuals with MPHUD. Methods We retrospectively analyzed 61 MPH patients (aged 16–27 years) admitted to the Beijing Gaoxin Hospital drug rehabilitation program from Jan 2017 to Mar 2019. The drug use history and drug abuse motivation scale were collected at admission. Clinicians rated the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and DSM-5 Stimulant use disorder criteria each week during the 4 weeks rehabilitation program. Correlation analyses were conducted between drug use history and affective disturbances. Results The results showed that the adolescent period is the peak for MPH exposure, and 1/3 of patients got their first exposure to MPH from their parents. MPH abstinence accompanies severe anxiety and depression symptoms, significantly alleviating after four weeks of treatment. Conclusions MPHUD is associated with substantial affective disturbances, which warrants a more considerable sample investigation. |
| first_indexed | 2024-04-14T03:02:19Z |
| format | Article |
| id | doaj.art-2ec23d258827406193e9009379f6957b |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-14T03:02:19Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-2ec23d258827406193e9009379f6957b2022-12-22T02:15:51ZengBMCBMC Psychiatry1471-244X2022-08-012211710.1186/s12888-022-04187-5Time-dependent affective disturbances in abstinent patients with methylphenidate use disorderJie Xu0Yi Zhang1Nan Wang2Pei Sun3Fuqiang Mao4Ti-Fei Yuan5Department of Psychiatry and Psychology, Tianjin Medical UniversityShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of MedicineDepartment of Psychiatry and Psychology, Tianjin Medical UniversityDepartment of Psychology, Tsinghua UniversityDepartment of Psychiatry and Psychology, Tianjin Medical UniversityShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of MedicineAbstract Background Methylphenidate (MPH), also called Ritalin, is used to treat attention-deficit hyperactivity disorder (ADHD) patients. With occasional reports of subjects suffering from Methylphenidate use disorder (MPHUD), few studies analyzed the neuropsychological changes in this population. Purpose This study aims to evaluate the clinical outcomes of individuals with MPHUD. Methods We retrospectively analyzed 61 MPH patients (aged 16–27 years) admitted to the Beijing Gaoxin Hospital drug rehabilitation program from Jan 2017 to Mar 2019. The drug use history and drug abuse motivation scale were collected at admission. Clinicians rated the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and DSM-5 Stimulant use disorder criteria each week during the 4 weeks rehabilitation program. Correlation analyses were conducted between drug use history and affective disturbances. Results The results showed that the adolescent period is the peak for MPH exposure, and 1/3 of patients got their first exposure to MPH from their parents. MPH abstinence accompanies severe anxiety and depression symptoms, significantly alleviating after four weeks of treatment. Conclusions MPHUD is associated with substantial affective disturbances, which warrants a more considerable sample investigation.https://doi.org/10.1186/s12888-022-04187-5MethylphenidateRitalinAddictionDepressionAnxietyAdolescents |
| spellingShingle | Jie Xu Yi Zhang Nan Wang Pei Sun Fuqiang Mao Ti-Fei Yuan Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder BMC Psychiatry Methylphenidate Ritalin Addiction Depression Anxiety Adolescents |
| title | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| title_full | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| title_fullStr | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| title_full_unstemmed | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| title_short | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| title_sort | time dependent affective disturbances in abstinent patients with methylphenidate use disorder |
| topic | Methylphenidate Ritalin Addiction Depression Anxiety Adolescents |
| url | https://doi.org/10.1186/s12888-022-04187-5 |
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