Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study
In this study, the prevalence and prognostic significance of the early repolarization (ER) pattern in the inferolateral leads in patients with Brugada syndrome were investigated. Clinical, genetic, and electrophysiological data were collected and analyzed from 69 individuals with either a spontaneou...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-10-01
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| Series: | Journal of Arrhythmia |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427612000592 |
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| author | Kimie Ohkubo Ichiro Watanabe Yasuo Okumura Masayoshi Kofune Koichi Nagashima Hiroaki Mano Kazumasa Sonoda Toshiko Nakai Yuji Kasamaki Atsushi Hirayama Naokata Sumitomo Tomohiro Nakayama |
| author_facet | Kimie Ohkubo Ichiro Watanabe Yasuo Okumura Masayoshi Kofune Koichi Nagashima Hiroaki Mano Kazumasa Sonoda Toshiko Nakai Yuji Kasamaki Atsushi Hirayama Naokata Sumitomo Tomohiro Nakayama |
| author_sort | Kimie Ohkubo |
| collection | DOAJ |
| description | In this study, the prevalence and prognostic significance of the early repolarization (ER) pattern in the inferolateral leads in patients with Brugada syndrome were investigated. Clinical, genetic, and electrophysiological data were collected and analyzed from 69 individuals with either a spontaneous or drug-induced Brugada type 1 electrocardiogram (ECG) pattern. An ER pattern was defined as J-point elevation at least 0.1 mV from the baseline in at least 2 inferior or lateral leads. The presence of late potentials and inducibility of ventricular fibrillation (VF) by programmed stimulation were compared between patients with and without a J wave. Follow-up data, including outcome events, were obtained for all patients. An ER pattern was observed in the inferolateral leads in 6 patients with a spontaneous Brugada type 1 ECG pattern and in 1 patient with a drug-induced Brugada type 1 ECG pattern. There was no significant intergroup difference in symptoms, family history of sudden cardiac death, prevalence of late potentials, or inducibility of VF. No patient with the ER pattern developed a cardiac event during the mean follow-up period of 73.6±38.1 months. The ER pattern in the inferolateral leads is not uncommon in Brugada syndrome; however, the presence of a J wave does not appear to be associated with subsequent arrhythmic events in patients with Brugada syndrome. |
| first_indexed | 2024-12-11T22:08:15Z |
| format | Article |
| id | doaj.art-2ec25f73578c465dbf02af3fed876792 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-12-11T22:08:15Z |
| publishDate | 2012-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-2ec25f73578c465dbf02af3fed8767922022-12-22T00:48:53ZengWileyJournal of Arrhythmia1880-42762012-10-0128527327610.1016/j.joa.2012.03.016Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center studyKimie Ohkubo0Ichiro Watanabe1Yasuo Okumura2Masayoshi Kofune3Koichi Nagashima4Hiroaki Mano5Kazumasa Sonoda6Toshiko Nakai7Yuji Kasamaki8Atsushi Hirayama9Naokata Sumitomo10Tomohiro Nakayama11Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanDepartment of Pediatrics, Nihon University School of Medicine, Tokyo, JapanDepartment of Laboratory Medicine, Nihon University School of Medicine, Tokyo, JapanIn this study, the prevalence and prognostic significance of the early repolarization (ER) pattern in the inferolateral leads in patients with Brugada syndrome were investigated. Clinical, genetic, and electrophysiological data were collected and analyzed from 69 individuals with either a spontaneous or drug-induced Brugada type 1 electrocardiogram (ECG) pattern. An ER pattern was defined as J-point elevation at least 0.1 mV from the baseline in at least 2 inferior or lateral leads. The presence of late potentials and inducibility of ventricular fibrillation (VF) by programmed stimulation were compared between patients with and without a J wave. Follow-up data, including outcome events, were obtained for all patients. An ER pattern was observed in the inferolateral leads in 6 patients with a spontaneous Brugada type 1 ECG pattern and in 1 patient with a drug-induced Brugada type 1 ECG pattern. There was no significant intergroup difference in symptoms, family history of sudden cardiac death, prevalence of late potentials, or inducibility of VF. No patient with the ER pattern developed a cardiac event during the mean follow-up period of 73.6±38.1 months. The ER pattern in the inferolateral leads is not uncommon in Brugada syndrome; however, the presence of a J wave does not appear to be associated with subsequent arrhythmic events in patients with Brugada syndrome.http://www.sciencedirect.com/science/article/pii/S1880427612000592Brugada syndromeEarly repolarization syndromeJ waveSudden cardiac death |
| spellingShingle | Kimie Ohkubo Ichiro Watanabe Yasuo Okumura Masayoshi Kofune Koichi Nagashima Hiroaki Mano Kazumasa Sonoda Toshiko Nakai Yuji Kasamaki Atsushi Hirayama Naokata Sumitomo Tomohiro Nakayama Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study Journal of Arrhythmia Brugada syndrome Early repolarization syndrome J wave Sudden cardiac death |
| title | Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study |
| title_full | Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study |
| title_fullStr | Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study |
| title_full_unstemmed | Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study |
| title_short | Prevalence and significance of the early repolarization pattern in inferolateral leads in patients with Brugada syndrome: A single-center study |
| title_sort | prevalence and significance of the early repolarization pattern in inferolateral leads in patients with brugada syndrome a single center study |
| topic | Brugada syndrome Early repolarization syndrome J wave Sudden cardiac death |
| url | http://www.sciencedirect.com/science/article/pii/S1880427612000592 |
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