Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes
The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus <i>Cinnamosma</i> (Canellaceae) are commonly used in traditional remedies...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
|
| Series: | Insects |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4450/10/11/373 |
| _version_ | 1818314750522556416 |
|---|---|
| author | Edna Alfaro Inocente Bao Nguyen Preston K. Manwill Annecie Benatrehina Eliningaya Kweka Sijin Wu Xiaolin Cheng L. Harinantenaina Rakotondraibe Peter M. Piermarini |
| author_facet | Edna Alfaro Inocente Bao Nguyen Preston K. Manwill Annecie Benatrehina Eliningaya Kweka Sijin Wu Xiaolin Cheng L. Harinantenaina Rakotondraibe Peter M. Piermarini |
| author_sort | Edna Alfaro Inocente |
| collection | DOAJ |
| description | The overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus <i>Cinnamosma</i> (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of <i>Cinnamosma</i> sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito <i>Aedes aegypti</i>. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from <i>Warburgia ugandensis</i> (Canellaceae) revealed that aldehydes are critical for—and a hydroxyl modulates—insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors. |
| first_indexed | 2024-12-13T08:54:36Z |
| format | Article |
| id | doaj.art-2ec47e61812b4257932805a9060680e8 |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-12-13T08:54:36Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-2ec47e61812b4257932805a9060680e82022-12-21T23:53:18ZengMDPI AGInsects2075-44502019-10-01101137310.3390/insects10110373insects10110373Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> MosquitoesEdna Alfaro Inocente0Bao Nguyen1Preston K. Manwill2Annecie Benatrehina3Eliningaya Kweka4Sijin Wu5Xiaolin Cheng6L. Harinantenaina Rakotondraibe7Peter M. Piermarini8Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USADepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USADepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USADepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USADepartment of Medical Parasitology, School of Medicine, Catholic University of Health and Allied Sciences-Bugando, Mwanza P.O. Box 1464, TanzaniaDepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USADepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USADepartments of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USADepartment of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USAThe overuse of insecticides with limited modes of action has led to resistance in mosquito vectors. Thus, insecticides with novel modes of action are needed. Secondary metabolites in Madagascan plants of the genus <i>Cinnamosma</i> (Canellaceae) are commonly used in traditional remedies and known to elicit antifeedant and toxic effects in insect pests. Here we test the hypothesis that extracts of <i>Cinnamosma</i> sp. enriched in drimane sesquiterpenes are toxic and/or antifeedant to the yellow fever mosquito <i>Aedes aegypti</i>. We show that the bark and root extracts, which contain a higher abundance of drimane sesquiterpenes compared to leaves, were the most efficacious. Screening isolated compounds revealed cinnamodial to be the primary driver of adulticidal activity, whereas cinnamodial, polygodial, cinnafragrin A, and capsicodendrin contributed to the larvicidal activity. Moreover, an abundant lactone (cinnamosmolide) in the root extract synergized the larvicidal effects of cinnamodial. The antifeedant activity of the extracts was primarily contributed to cinnamodial, polygodial, and cinnamolide. Parallel experiments with warburganal isolated from <i>Warburgia ugandensis</i> (Canellaceae) revealed that aldehydes are critical for—and a hydroxyl modulates—insecticidal activity. Our results indicate that plant drimane sesquiterpenes provide valuable chemical platforms for developing insecticides and repellents to control mosquito vectors.https://www.mdpi.com/2075-4450/10/11/373<i>aedes aegypti</i><i>cinnamosma</i><i>warburgia</i>insecticideantifeedant |
| spellingShingle | Edna Alfaro Inocente Bao Nguyen Preston K. Manwill Annecie Benatrehina Eliningaya Kweka Sijin Wu Xiaolin Cheng L. Harinantenaina Rakotondraibe Peter M. Piermarini Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes Insects <i>aedes aegypti</i> <i>cinnamosma</i> <i>warburgia</i> insecticide antifeedant |
| title | Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes |
| title_full | Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes |
| title_fullStr | Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes |
| title_full_unstemmed | Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes |
| title_short | Insecticidal and Antifeedant Activities of Malagasy Medicinal Plant (<i>Cinnamosma</i> sp.) Extracts and Drimane-Type Sesquiterpenes against <i>Aedes aegypti</i> Mosquitoes |
| title_sort | insecticidal and antifeedant activities of malagasy medicinal plant i cinnamosma i sp extracts and drimane type sesquiterpenes against i aedes aegypti i mosquitoes |
| topic | <i>aedes aegypti</i> <i>cinnamosma</i> <i>warburgia</i> insecticide antifeedant |
| url | https://www.mdpi.com/2075-4450/10/11/373 |
| work_keys_str_mv | AT ednaalfaroinocente insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT baonguyen insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT prestonkmanwill insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT anneciebenatrehina insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT eliningayakweka insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT sijinwu insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT xiaolincheng insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT lharinantenainarakotondraibe insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes AT petermpiermarini insecticidalandantifeedantactivitiesofmalagasymedicinalplanticinnamosmaispextractsanddrimanetypesesquiterpenesagainstiaedesaegyptiimosquitoes |