Improved GPCR ligands from nanobody tethering
Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15884-8 |
| _version_ | 1828976697106497536 |
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| author | Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh |
| author_facet | Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh |
| author_sort | Ross W. Cheloha |
| collection | DOAJ |
| description | Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors. |
| first_indexed | 2024-12-14T14:43:28Z |
| format | Article |
| id | doaj.art-2ec526511b22420986044ab4ea9c3e47 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:43:28Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ec526511b22420986044ab4ea9c3e472022-12-21T22:57:21ZengNature PortfolioNature Communications2041-17232020-04-0111111110.1038/s41467-020-15884-8Improved GPCR ligands from nanobody tetheringRoss W. Cheloha0Fabian A. Fischer1Andrew W. Woodham2Eileen Daley3Naomi Suminski4Thomas J. Gardella5Hidde L. Ploegh6Boston Children’s Hospital and Harvard Medical School, 1 Blackfan CircleBoston Children’s Hospital and Harvard Medical School, 1 Blackfan CircleBoston Children’s Hospital and Harvard Medical School, 1 Blackfan CircleMassachusetts General Hospital and Harvard Medical School, 50 Blossom StreetBoston Children’s Hospital and Harvard Medical School, 1 Blackfan CircleMassachusetts General Hospital and Harvard Medical School, 50 Blossom StreetBoston Children’s Hospital and Harvard Medical School, 1 Blackfan CircleAntibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.https://doi.org/10.1038/s41467-020-15884-8 |
| spellingShingle | Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh Improved GPCR ligands from nanobody tethering Nature Communications |
| title | Improved GPCR ligands from nanobody tethering |
| title_full | Improved GPCR ligands from nanobody tethering |
| title_fullStr | Improved GPCR ligands from nanobody tethering |
| title_full_unstemmed | Improved GPCR ligands from nanobody tethering |
| title_short | Improved GPCR ligands from nanobody tethering |
| title_sort | improved gpcr ligands from nanobody tethering |
| url | https://doi.org/10.1038/s41467-020-15884-8 |
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