Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF)

Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF)

Aims: Adiponectin has been shown to mediate cardioprotective effects and levels are typically reduced in patients with cardiometabolic disease. Hence, there has been intense interest in developing adiponectin-based therapeutics. The aim of this translational research study was to examine the functio...

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Bibliographic Details
Main Authors: Sungji Cho, Keith Dadson, Hye Kyoung Sung, Oyeronke Ayansola, Ali Mirzaesmaeili, Nina Noskovicova, Yimu Zhao, Krisco Cheung, Milica Radisic, Boris Hinz, Ali A. Abdul Sater, Henry H. Hsu, Gary D. Lopaschuk, Gary Sweeney
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Adiponectin
Heart failure
Therapeutic
Fibrosis
Inflammation
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223019170

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http://www.sciencedirect.com/science/article/pii/S0753332223019170

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