Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression

Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression

BackgroundMood disorders associate with peripheral markers of low-grade inflammation, among which circulating levels of interleukin-1β (IL-1β) consistently predict diagnosis and poor outcomes. Antidepressant chronotherapeutics (total sleep deprivation and light therapy, TSD+LT) prompts response in d...

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Bibliographic Details
Main Authors: Francesco Benedetti, Sara Dallaspezia, Elisa Maria Teresa Melloni, Cristina Lorenzi, Raffaella Zanardi, Barbara Barbini, Cristina Colombo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
chronotherapeutics
sleep deprivation
light therapy
inflammation
interleukin-1β
antidepressant
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.740686/full

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