Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center
Urinary tract infections (UTI) are one of the most common community acquired infections and can also present with similar lower urinary tract symptoms (LUTS). Moreover, UTI can be a complication of these urological diseases. Thus, this study was conducted in patients with LUTS to find out the preval...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2020-09-01
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| Series: | Journal of Pure and Applied Microbiology |
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| Online Access: | https://microbiologyjournal.org/prevalence-of-community-acquired-uropathogens-and-their-antimicrobial-susceptibility-in-patients-from-the-urology-unit-of-a-tertiary-care-medical-center/ |
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| author | Manzoor Ahmad Pushkar Kumar Asfia Sultan Anees Akhtar Bhanu Chaudhary Fatima Khan |
| author_facet | Manzoor Ahmad Pushkar Kumar Asfia Sultan Anees Akhtar Bhanu Chaudhary Fatima Khan |
| author_sort | Manzoor Ahmad |
| collection | DOAJ |
| description | Urinary tract infections (UTI) are one of the most common community acquired infections and can also present with similar lower urinary tract symptoms (LUTS). Moreover, UTI can be a complication of these urological diseases. Thus, this study was conducted in patients with LUTS to find out the prevalence of uro-pathogens and their antibiotic susceptibility pattern so that appropriate antibiotics can be started on clinical suspicion of UTI. The study was conducted over a period of 12 months. Culture and susceptibility of urine specimen was done as per standard microbiological guidelines. Apart from the growth of common bacteria with their antibiogram, Methicillin-resistant Staphylococcus aureus (MRSA), high level aminoglycoside resistance (HLAR) was investigated among Enterococci, and metallo beta-lactamases(MBL) production was production was investigated among gram-negative pathogens. Out of 407 urine samples included in the study, 80 (19.6%) samples showed bacterial growth. The commonest isolate was E. coli 44 (55 %). Majority of the isolates were multidrug resistant with two E.coli strains showing pan-resistance to the first line drugs tested. Carbapenem resistance was seen in 67.2% of all gram negative isolates tested. Metallo beta-lactamases production was found to be highest among the Klebsiella isolates. Among the Enterobacterales, highest susceptibility was noted to Fosfomycin (87.7%) followed by Nitrofurantoin (62.7%). Similarly in gram positive group, highest susceptibility was again to Fosfomycin followed by Nitrofurantoin. Overall the prevalence of MDR is increasing however Fosfomycin or Nitrofurantoin, both oral antibiotics, can be the considered for starting empirical antibiotic therapy. |
| first_indexed | 2024-12-19T00:13:52Z |
| format | Article |
| id | doaj.art-2ec9ef5260e6464eb5fb8b62f874e804 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-19T00:13:52Z |
| publishDate | 2020-09-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-2ec9ef5260e6464eb5fb8b62f874e8042022-12-21T20:45:56ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2020-09-011432009201510.22207/JPAM.14.3.40Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical CenterManzoor AhmadPushkar Kumarhttps://orcid.org/0000-0002-9828-2426Asfia Sultanhttps://orcid.org/0000-0003-0343-9513Anees Akhtarhttps://orcid.org/0000-0002-4411-9914Bhanu Chaudharyhttps://orcid.org/0000-0002-1247-7717Fatima Khanhttps://orcid.org/0000-0002-7629-0935Urinary tract infections (UTI) are one of the most common community acquired infections and can also present with similar lower urinary tract symptoms (LUTS). Moreover, UTI can be a complication of these urological diseases. Thus, this study was conducted in patients with LUTS to find out the prevalence of uro-pathogens and their antibiotic susceptibility pattern so that appropriate antibiotics can be started on clinical suspicion of UTI. The study was conducted over a period of 12 months. Culture and susceptibility of urine specimen was done as per standard microbiological guidelines. Apart from the growth of common bacteria with their antibiogram, Methicillin-resistant Staphylococcus aureus (MRSA), high level aminoglycoside resistance (HLAR) was investigated among Enterococci, and metallo beta-lactamases(MBL) production was production was investigated among gram-negative pathogens. Out of 407 urine samples included in the study, 80 (19.6%) samples showed bacterial growth. The commonest isolate was E. coli 44 (55 %). Majority of the isolates were multidrug resistant with two E.coli strains showing pan-resistance to the first line drugs tested. Carbapenem resistance was seen in 67.2% of all gram negative isolates tested. Metallo beta-lactamases production was found to be highest among the Klebsiella isolates. Among the Enterobacterales, highest susceptibility was noted to Fosfomycin (87.7%) followed by Nitrofurantoin (62.7%). Similarly in gram positive group, highest susceptibility was again to Fosfomycin followed by Nitrofurantoin. Overall the prevalence of MDR is increasing however Fosfomycin or Nitrofurantoin, both oral antibiotics, can be the considered for starting empirical antibiotic therapy.https://microbiologyjournal.org/prevalence-of-community-acquired-uropathogens-and-their-antimicrobial-susceptibility-in-patients-from-the-urology-unit-of-a-tertiary-care-medical-center/utiantimicrobial resistanceurologylutsboo |
| spellingShingle | Manzoor Ahmad Pushkar Kumar Asfia Sultan Anees Akhtar Bhanu Chaudhary Fatima Khan Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center Journal of Pure and Applied Microbiology uti antimicrobial resistance urology luts boo |
| title | Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center |
| title_full | Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center |
| title_fullStr | Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center |
| title_full_unstemmed | Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center |
| title_short | Prevalence of Community Acquired Uropathogens and their Antimicrobial Susceptibility in Patients from the Urology Unit of A Tertiary Care Medical Center |
| title_sort | prevalence of community acquired uropathogens and their antimicrobial susceptibility in patients from the urology unit of a tertiary care medical center |
| topic | uti antimicrobial resistance urology luts boo |
| url | https://microbiologyjournal.org/prevalence-of-community-acquired-uropathogens-and-their-antimicrobial-susceptibility-in-patients-from-the-urology-unit-of-a-tertiary-care-medical-center/ |
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