Defective hippocampal astrocyte and neuronal primary cilia function in offspring brain of pregnant rats with advanced age might be associated with promoting apoptosis through LKB1/AMPK pathway

Defective hippocampal astrocyte and neuronal primary cilia function in offspring brain of pregnant rats with advanced age might be associated with promoting apoptosis through LKB1/AMPK pathway

Objective Objective To investigate the changes in hippocampal astrocytes and neuronal primary cilia, and neuronal apoptosis in the offspring brain of advanced maternal age and the role of LKB1/AMPK pathway. Methods The 12-month-old SD female rats were mated with 3-month-old SD male rats to produce o...

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Bibliographic Details
Main Authors: HAN Ziyao, LUO Hanyu, GUI Jianxiong, YUAN Ping, JIANG Li
Format: Article
Language:zho
Published: Editorial Office of Journal of Army Medical University 2023-06-01
Series:陆军军医大学学报
Subjects:
advanced maternal age
offspring
hippocampus
neurons
primary cilia
apoptosis
lkb1/ampk pathway
Online Access:http://aammt.tmmu.edu.cn/html/202304096.htm

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