Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study
Aim: To evaluate the histologic and histomorphometric effects of hyaluronic acid (HA) gel with or without acellular dermal matrix allograft (ADMA) on periodontal regeneration in Class II furcation defects in dogs. Materials and methods: Class II furcation defects were surgically created in the mandi...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223001207 |
| _version_ | 1827777342126161920 |
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| author | Eman A. Tella Salwa A. Aldahlawi Ehab T. Azab Wael E. Yaghmoor Hoda A. Fansa |
| author_facet | Eman A. Tella Salwa A. Aldahlawi Ehab T. Azab Wael E. Yaghmoor Hoda A. Fansa |
| author_sort | Eman A. Tella |
| collection | DOAJ |
| description | Aim: To evaluate the histologic and histomorphometric effects of hyaluronic acid (HA) gel with or without acellular dermal matrix allograft (ADMA) on periodontal regeneration in Class II furcation defects in dogs. Materials and methods: Class II furcation defects were surgically created in the mandibular first and second premolars bilaterally in eight beagle dogs. The Class II furcation defects were assigned randomly, using the split-mouth design, into the test and control sides. The teeth on the test sides were equally and randomly divided into the HA/ADMA group (n = 8) treated with 0.8% HA gel followed by ADMA, and the HA-only group (n = 8) treated with 0.8% HA only. The furcation defects of the control sides (n = 16) were subjected to open flap debridement (OFD group). The animals were euthanized for histologic and histomorphometric analyses after one month (n = 4) and three months (n = 4). Results: At one month, the newly formed bone area (NFBA) was larger in the HA/ADMA (6.23 ± 1.41 mm2) and HA-only (5.90 ± 1.43 mm2) groups than in the OFD group (2.42 ± 1.62 mm2) (p < 0.05). The newly formed cementum (NFAC) and periodontal ligament (NFPL) were similar in the HA/ADMA and HA-only groups but significantly lesser in the OFD group (p < 0.05.) At three months, the NFBA, NFAC, and NFPL were greater in the HA/ADMA group than in the HA-only group (p < 0.05). New regenerative tissue was significantly greater in both the test groups than in the OFD group (p < 0.05), while epithelial downgrowth predominated the healing in the latter. Conclusions: These results suggest that HA with ADMA positively affects the periodontal regeneration and wound healing in Class II furcation defects. |
| first_indexed | 2024-03-11T14:16:59Z |
| format | Article |
| id | doaj.art-2ecc1aa249cb4f808c13316d5ce1ebe9 |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-03-11T14:16:59Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-2ecc1aa249cb4f808c13316d5ce1ebe92023-11-01T04:46:16ZengElsevierSaudi Dental Journal1013-90522023-11-01357845853Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric studyEman A. Tella0Salwa A. Aldahlawi1Ehab T. Azab2Wael E. Yaghmoor3Hoda A. Fansa4Department of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al-Qura University, Saudi ArabiaDepartment of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al-Qura University, Saudi Arabia; Corresponding author at: Department of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al- Qura University, Makkah, Saudi Arabia.Department of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al-Qura University, Saudi ArabiaDepartment of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al-Qura University, Saudi ArabiaDepartment of Basic and Clinical Oral Sciences, Faculty of Dental Medicine, Umm Al-Qura University, Saudi Arabia; Department of Oral Biology, Faculty of Dentistry, Alexandra University, EgyptAim: To evaluate the histologic and histomorphometric effects of hyaluronic acid (HA) gel with or without acellular dermal matrix allograft (ADMA) on periodontal regeneration in Class II furcation defects in dogs. Materials and methods: Class II furcation defects were surgically created in the mandibular first and second premolars bilaterally in eight beagle dogs. The Class II furcation defects were assigned randomly, using the split-mouth design, into the test and control sides. The teeth on the test sides were equally and randomly divided into the HA/ADMA group (n = 8) treated with 0.8% HA gel followed by ADMA, and the HA-only group (n = 8) treated with 0.8% HA only. The furcation defects of the control sides (n = 16) were subjected to open flap debridement (OFD group). The animals were euthanized for histologic and histomorphometric analyses after one month (n = 4) and three months (n = 4). Results: At one month, the newly formed bone area (NFBA) was larger in the HA/ADMA (6.23 ± 1.41 mm2) and HA-only (5.90 ± 1.43 mm2) groups than in the OFD group (2.42 ± 1.62 mm2) (p < 0.05). The newly formed cementum (NFAC) and periodontal ligament (NFPL) were similar in the HA/ADMA and HA-only groups but significantly lesser in the OFD group (p < 0.05.) At three months, the NFBA, NFAC, and NFPL were greater in the HA/ADMA group than in the HA-only group (p < 0.05). New regenerative tissue was significantly greater in both the test groups than in the OFD group (p < 0.05), while epithelial downgrowth predominated the healing in the latter. Conclusions: These results suggest that HA with ADMA positively affects the periodontal regeneration and wound healing in Class II furcation defects.http://www.sciencedirect.com/science/article/pii/S1013905223001207BiomaterialsAcellular dermal matrix allograftFurcation defectHyaluronic acidPeriodontal regenerationWound healing |
| spellingShingle | Eman A. Tella Salwa A. Aldahlawi Ehab T. Azab Wael E. Yaghmoor Hoda A. Fansa Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study Saudi Dental Journal Biomaterials Acellular dermal matrix allograft Furcation defect Hyaluronic acid Periodontal regeneration Wound healing |
| title | Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study |
| title_full | Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study |
| title_fullStr | Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study |
| title_full_unstemmed | Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study |
| title_short | Evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class II furcation defects in dogs: A histologic and histomorphometric study |
| title_sort | evaluation of hyaluronic acid gel with or without acellular dermal matrix allograft in the treatment of class ii furcation defects in dogs a histologic and histomorphometric study |
| topic | Biomaterials Acellular dermal matrix allograft Furcation defect Hyaluronic acid Periodontal regeneration Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223001207 |
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