Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals
Background: Growth incidents usually progress in a fairly expected sequence; however, their timing and pattern vary across individual subjects. Biochemical biomarkers have an association with bone metabolism and produce signals which stimulate the growth and development of various craniofacial struc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905222000578 |
| _version_ | 1811329256725151744 |
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| author | Sarah Z. Al Meshari AlJazi H. Aldweesh |
| author_facet | Sarah Z. Al Meshari AlJazi H. Aldweesh |
| author_sort | Sarah Z. Al Meshari |
| collection | DOAJ |
| description | Background: Growth incidents usually progress in a fairly expected sequence; however, their timing and pattern vary across individual subjects. Biochemical biomarkers have an association with bone metabolism and produce signals which stimulate the growth and development of various craniofacial structures. Steroid dehydroepiandrosterone sulfate (DHEA-S) plays a major role in the initiation of growth hormone actions which has a significant role in promoting and accelerating skeletal maturation during puberty. The aim of this study was to investigate the correlation between salivary DHEA-S levels and cervical vertebral maturation (CVM) stages throughout the circumpubertal developmental period. Methods: One hundred forty-one participants (70 males and 71 females), between 7 and 23years of age, were categorized into six cervical stages (CS) based on lateral cephalograms. Using a passive drooling technique, unstimulated whole saliva samples were collected from all enrolled subjects. DHEA-S levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) and correlated with the six CVM stages. Results: One-way analysis of variance ANOVA showed that the mean salivary DHEA-S levels at CS 3 and CS 4 were significantly different from the values recorded at other stages, and the two stages were statistically significant from each other. Pearson linear correlation of mean salivary DHEA-S levels from CS 1 to CS 6 showed a significant positive correlation. Conclusion: Salivary DHEA-S can be used as a non-invasive indicator for detecting the pubertal growth spurt. |
| first_indexed | 2024-04-13T15:40:37Z |
| format | Article |
| id | doaj.art-2ecf3bcc74f847628ae7138efb3394e6 |
| institution | Directory Open Access Journal |
| issn | 1013-9052 |
| language | English |
| last_indexed | 2024-04-13T15:40:37Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj.art-2ecf3bcc74f847628ae7138efb3394e62022-12-22T02:41:10ZengElsevierSaudi Dental Journal1013-90522022-07-01345355361Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individualsSarah Z. Al Meshari0AlJazi H. Aldweesh1Corresponding author at: Graduate Studies and Scientific Research, Orthodontics Department, College of Dentistry, King Saud University, P.O. Box 60169-15, Riyadh 11545, Saudi Arabia; Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi ArabiaDepartment of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi ArabiaBackground: Growth incidents usually progress in a fairly expected sequence; however, their timing and pattern vary across individual subjects. Biochemical biomarkers have an association with bone metabolism and produce signals which stimulate the growth and development of various craniofacial structures. Steroid dehydroepiandrosterone sulfate (DHEA-S) plays a major role in the initiation of growth hormone actions which has a significant role in promoting and accelerating skeletal maturation during puberty. The aim of this study was to investigate the correlation between salivary DHEA-S levels and cervical vertebral maturation (CVM) stages throughout the circumpubertal developmental period. Methods: One hundred forty-one participants (70 males and 71 females), between 7 and 23years of age, were categorized into six cervical stages (CS) based on lateral cephalograms. Using a passive drooling technique, unstimulated whole saliva samples were collected from all enrolled subjects. DHEA-S levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) and correlated with the six CVM stages. Results: One-way analysis of variance ANOVA showed that the mean salivary DHEA-S levels at CS 3 and CS 4 were significantly different from the values recorded at other stages, and the two stages were statistically significant from each other. Pearson linear correlation of mean salivary DHEA-S levels from CS 1 to CS 6 showed a significant positive correlation. Conclusion: Salivary DHEA-S can be used as a non-invasive indicator for detecting the pubertal growth spurt.http://www.sciencedirect.com/science/article/pii/S1013905222000578SalivaBiomarkerDehydroepiandrosterone sulfate DHEA-SSkeletal maturity indicatorGrowth assessmentCephalometric radiograph |
| spellingShingle | Sarah Z. Al Meshari AlJazi H. Aldweesh Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals Saudi Dental Journal Saliva Biomarker Dehydroepiandrosterone sulfate DHEA-S Skeletal maturity indicator Growth assessment Cephalometric radiograph |
| title | Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals |
| title_full | Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals |
| title_fullStr | Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals |
| title_full_unstemmed | Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals |
| title_short | Correlation between salivary dehydroepiandrosterone sulfate (DHEA-S) levels and cervical vertebral maturation in Saudi individuals |
| title_sort | correlation between salivary dehydroepiandrosterone sulfate dhea s levels and cervical vertebral maturation in saudi individuals |
| topic | Saliva Biomarker Dehydroepiandrosterone sulfate DHEA-S Skeletal maturity indicator Growth assessment Cephalometric radiograph |
| url | http://www.sciencedirect.com/science/article/pii/S1013905222000578 |
| work_keys_str_mv | AT sarahzalmeshari correlationbetweensalivarydehydroepiandrosteronesulfatedheaslevelsandcervicalvertebralmaturationinsaudiindividuals AT aljazihaldweesh correlationbetweensalivarydehydroepiandrosteronesulfatedheaslevelsandcervicalvertebralmaturationinsaudiindividuals |