Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial
Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to...
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2018-11-01
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| Series: | Jorjani Biomedicine Journal |
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| Online Access: | http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-494-1&slc_lang=en&sid=1 |
| _version_ | 1818516485331484672 |
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| author | Zahra Roustaeizade Mohamad Hassan Akhavan Karbassi Khatereh Kheirollahi Ehsan Babaei zarch |
| author_facet | Zahra Roustaeizade Mohamad Hassan Akhavan Karbassi Khatereh Kheirollahi Ehsan Babaei zarch |
| author_sort | Zahra Roustaeizade |
| collection | DOAJ |
| description | Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS.
Methods: In this randomized, double-blind clinical trial, 60 patients with RAS were evaluated. Thirty patients used myrtex extract 5% and thirty patients used myrtex extract 2.5% (10 drops on lesion for 20 seconds 5 times per day). The severity of pain and burning sensation experienced by patients were measured by visual analogue scale (VAS) and the size of the lesion was estimated by transparent calibrated grid Data analysis was done by running t-test and repeated measures statistical test.
Results: The mean of the largest RAS diameter before treatment was decreased in both groups 1 day and 7 days after treatment (P-value=0.000); however, these differences were not significant in both groups (P-value =0.401). Furthermore, the severities of pain and burning sensation were decreased in both groups (p-value = 0.000). Nevertheless, this decrease was similar in both groups (P-value = 964).
Conclusion: Treatment with different concentrations of myrtex extract is effective in decreasing RAS diameter, pain, and burning sensation. In addition, the therapeutic efficacy of two different concentrations of myrtex extract (2.5% and 5%) was similar in this regard. |
| first_indexed | 2024-12-11T00:42:54Z |
| format | Article |
| id | doaj.art-2ecfb231fda64bf0b32dbc7e35dc83d3 |
| institution | Directory Open Access Journal |
| issn | 2645-3509 |
| language | English |
| last_indexed | 2024-12-11T00:42:54Z |
| publishDate | 2018-11-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Jorjani Biomedicine Journal |
| spelling | doaj.art-2ecfb231fda64bf0b32dbc7e35dc83d32022-12-22T01:26:52ZengGolestan University of Medical SciencesJorjani Biomedicine Journal2645-35092018-11-01636371Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical TrialZahra Roustaeizade0Mohamad Hassan Akhavan Karbassi1Khatereh Kheirollahi2Ehsan Babaei zarch3 Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Faculty of Dentistry, Shahid Sadoughi University of Medical Science, Yazd, Iran Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS. Methods: In this randomized, double-blind clinical trial, 60 patients with RAS were evaluated. Thirty patients used myrtex extract 5% and thirty patients used myrtex extract 2.5% (10 drops on lesion for 20 seconds 5 times per day). The severity of pain and burning sensation experienced by patients were measured by visual analogue scale (VAS) and the size of the lesion was estimated by transparent calibrated grid Data analysis was done by running t-test and repeated measures statistical test. Results: The mean of the largest RAS diameter before treatment was decreased in both groups 1 day and 7 days after treatment (P-value=0.000); however, these differences were not significant in both groups (P-value =0.401). Furthermore, the severities of pain and burning sensation were decreased in both groups (p-value = 0.000). Nevertheless, this decrease was similar in both groups (P-value = 964). Conclusion: Treatment with different concentrations of myrtex extract is effective in decreasing RAS diameter, pain, and burning sensation. In addition, the therapeutic efficacy of two different concentrations of myrtex extract (2.5% and 5%) was similar in this regard.http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-494-1&slc_lang=en&sid=1Recurrent Aphthous StomatitisMyrtle extractMyrtus communis |
| spellingShingle | Zahra Roustaeizade Mohamad Hassan Akhavan Karbassi Khatereh Kheirollahi Ehsan Babaei zarch Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial Jorjani Biomedicine Journal Recurrent Aphthous Stomatitis Myrtle extract Myrtus communis |
| title | Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial |
| title_full | Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial |
| title_fullStr | Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial |
| title_full_unstemmed | Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial |
| title_short | Therapeutic Efficacy of Different Concentrations of Myrtus communis (Essential oil of common myrtle) in the Treatment of Recurrent Aphthous Stomatitis: A Randomized Controlled Clinical Trial |
| title_sort | therapeutic efficacy of different concentrations of myrtus communis essential oil of common myrtle in the treatment of recurrent aphthous stomatitis a randomized controlled clinical trial |
| topic | Recurrent Aphthous Stomatitis Myrtle extract Myrtus communis |
| url | http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-494-1&slc_lang=en&sid=1 |
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