A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration

We describe the construction and phenotypic analysis of a human embryonic stem cell model of progressive Aβ-dependent neurodegeneration (ND) with potential relevance to Alzheimer’s disease (AD). We modified one allele of the normal APP locus to directly express a secretory form of Aβ40 or Aβ42, enab...

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Bibliographic Details
Main Authors:	Teresa Ubina, Martha Magallanes, Saumya Srivastava, Charles D. Warden, Jiing-Kuan Yee, Paul M. Salvaterra
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-09-01
Series:	Frontiers in Neuroscience
Subjects:	amyloid-beta neurodegeneration stem cells Alzheimer’s disease Alzheimer’s model
Online Access:	https://www.frontiersin.org/article/10.3389/fnins.2019.01007/full

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