Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing
BackgroundAs an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment in children with sleep-disordered breathing (SDB). The main aim of this study was to compare the levels of BDNF and tyrosine kinase receptor B (TrkB) in normal c...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1027894/full |
| _version_ | 1797939145973170176 |
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| author | Yani Feng Lina Ma Xi Chen Yitong Zhang Zine Cao Yuqi Yuan Yushan Xie Haiqin Liu Yewen Shi Xiaoyong Ren |
| author_facet | Yani Feng Lina Ma Xi Chen Yitong Zhang Zine Cao Yuqi Yuan Yushan Xie Haiqin Liu Yewen Shi Xiaoyong Ren |
| author_sort | Yani Feng |
| collection | DOAJ |
| description | BackgroundAs an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment in children with sleep-disordered breathing (SDB). The main aim of this study was to compare the levels of BDNF and tyrosine kinase receptor B (TrkB) in normal children and those with obstructive sleep apnea (OSA) and primary snoring (PS) and to explore a possible link between BDNF/TrkB, inflammation, and SDB with cognitive impairment in children.MethodsA total of 44 OSA children and 35 PS children who completed polysomnography between October 2017 and October 2019 were enrolled. At the same time, 40 healthy children during the same period were included as a control. Enzyme-linked immunosorbent assay was used to measure serum indices of BDNF, TrkB, interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α). Correlation and pooled analyses were performed between the cognitive scores and four serological indicators. Logistic regression was used to analyze the risk factors for cognitive impairment.ResultsSignificant differences were found in serum BDNF, TrkB, IL-1β, and TNF-α between the three groups (all P < 0.01). The serum BDNF and TrkB in the OSA and PS groups were lower than those in the control group, whereas the serum IL-1β and TNF-α were higher than those in the control group (all P < 0.05). Moreover, among these four indices, the strongest correlation was found between BDNF and the Chinese Wechsler Intelligence Scale (all P < 0.05). Logistic regression analysis revealed a correlation between OSA status, TrkB, and course of mouth breathing and cognitive status.ConclusionThe levels of serum BDNF and TrkB were related to cognitive impairment in children with SDB. Also, BDNF and TrkB could be used as noninvasive and objective candidate markers and predictive indices of cognitive impairment in children with SDB. |
| first_indexed | 2024-04-10T19:10:48Z |
| format | Article |
| id | doaj.art-2ecff0b096d9432db6bd327985048fd3 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T19:10:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-2ecff0b096d9432db6bd327985048fd32023-01-30T14:45:52ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-01-011010.3389/fped.2022.10278941027894Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathingYani FengLina MaXi ChenYitong ZhangZine CaoYuqi YuanYushan XieHaiqin LiuYewen ShiXiaoyong RenBackgroundAs an important neuroprotective factor, the brain-derived neurotrophic factor (BDNF) may have a key role in cognitive impairment in children with sleep-disordered breathing (SDB). The main aim of this study was to compare the levels of BDNF and tyrosine kinase receptor B (TrkB) in normal children and those with obstructive sleep apnea (OSA) and primary snoring (PS) and to explore a possible link between BDNF/TrkB, inflammation, and SDB with cognitive impairment in children.MethodsA total of 44 OSA children and 35 PS children who completed polysomnography between October 2017 and October 2019 were enrolled. At the same time, 40 healthy children during the same period were included as a control. Enzyme-linked immunosorbent assay was used to measure serum indices of BDNF, TrkB, interleukin-1beta (IL-1β), and tumor necrosis factor-alpha (TNF-α). Correlation and pooled analyses were performed between the cognitive scores and four serological indicators. Logistic regression was used to analyze the risk factors for cognitive impairment.ResultsSignificant differences were found in serum BDNF, TrkB, IL-1β, and TNF-α between the three groups (all P < 0.01). The serum BDNF and TrkB in the OSA and PS groups were lower than those in the control group, whereas the serum IL-1β and TNF-α were higher than those in the control group (all P < 0.05). Moreover, among these four indices, the strongest correlation was found between BDNF and the Chinese Wechsler Intelligence Scale (all P < 0.05). Logistic regression analysis revealed a correlation between OSA status, TrkB, and course of mouth breathing and cognitive status.ConclusionThe levels of serum BDNF and TrkB were related to cognitive impairment in children with SDB. Also, BDNF and TrkB could be used as noninvasive and objective candidate markers and predictive indices of cognitive impairment in children with SDB.https://www.frontiersin.org/articles/10.3389/fped.2022.1027894/fullsleep-disordered breathingBDNFtrkBcognitive impairmentpediatric |
| spellingShingle | Yani Feng Lina Ma Xi Chen Yitong Zhang Zine Cao Yuqi Yuan Yushan Xie Haiqin Liu Yewen Shi Xiaoyong Ren Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing Frontiers in Pediatrics sleep-disordered breathing BDNF trkB cognitive impairment pediatric |
| title | Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing |
| title_full | Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing |
| title_fullStr | Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing |
| title_full_unstemmed | Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing |
| title_short | Relationship between serum brain-derived neurotrophic factor and cognitive impairment in children with sleep-disordered breathing |
| title_sort | relationship between serum brain derived neurotrophic factor and cognitive impairment in children with sleep disordered breathing |
| topic | sleep-disordered breathing BDNF trkB cognitive impairment pediatric |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1027894/full |
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