Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction
Purpose: In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other h...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00281/full |
| _version_ | 1819229676350996480 |
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| author | Carmine Bruno Carmine Bruno Andrea Silvestrini Andrea Silvestrini Rodolfo Calarco Rodolfo Calarco Angela M. R. Favuzzi Angela M. R. Favuzzi Edoardo Vergani Edoardo Vergani Maria Anna Nicolazzi Maria Anna Nicolazzi Claudia d'Abate Claudia d'Abate Elisabetta Meucci Elisabetta Meucci Alvaro Mordente Alvaro Mordente Raffaele Landolfi Raffaele Landolfi Antonio Mancini Antonio Mancini |
| author_facet | Carmine Bruno Carmine Bruno Andrea Silvestrini Andrea Silvestrini Rodolfo Calarco Rodolfo Calarco Angela M. R. Favuzzi Angela M. R. Favuzzi Edoardo Vergani Edoardo Vergani Maria Anna Nicolazzi Maria Anna Nicolazzi Claudia d'Abate Claudia d'Abate Elisabetta Meucci Elisabetta Meucci Alvaro Mordente Alvaro Mordente Raffaele Landolfi Raffaele Landolfi Antonio Mancini Antonio Mancini |
| author_sort | Carmine Bruno |
| collection | DOAJ |
| description | Purpose: In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other hand, oxidative stress is recognized as a player in the pathogenesis of HFpEF. Therefore, we performed a cohort study in HFpEF aimed to (1) define the multi-hormonal deficiency prevalence in HFpEF patients; (2) investigate the relationships between hormonal deficiencies and echocardiographic indexes; (3) explore the modulatory activity of anabolic hormones on antioxidant systems.Methods: 84 patients with diagnosis of HFpEF were enrolled in the study. Plasma levels of N-terminal pro-brain natriuretic peptide, fasting glucose, insulin, lipid pattern, insulin-like growth factor-1, dehydroepiandrosterone-sulfate (DHEA-S), total testosterone (T, only in male subjects) were evaluated. Hormonal deficiencies were defined according to T.O.S.C.A. multi-centric study, as previously published. An echocardiographic evaluation was performed. Plasma total antioxidant capacity (TAC) was measured using the system metmyoglobin –H2O2 and the chromogen ABTS, whose radical form is spectroscopically revealed; latency time (LAG) in the appearance of ABTS• is proportional to antioxidants in sample.Results: Multiple deficiencies were discovered. DHEA-S deficiency in 87% of patients, IGF-1 in 67% of patients, T in 42%. Patients with DHEA-S deficiency showed lower levels of TAC expressed by LAG (mean ± SEM 91.25 ± 9.34 vs. 75.22 ± 4.38 s; p < 0.05). No differences between TAC in patients with or without IGF-1 deficiency were found. A trend toward high level of TAC in patients without hormonal deficiencies compared with patients with one or multiple deficiencies was found. Regarding echocardiographic parameters, Left Atrial and Left Atrial Volume Index were significantly higher in patients with low IGF-1 values (mean ± SD 90.84 ± 3.86 vs. 72.83 ± 3.78 mL; 51.03 ± 2.33 vs. 40.56 ± 2.46 mL/m2, respectively; p < 0.05).Conclusions: Our study showed high prevalence of anabolic deficiencies in HFpEF. DHEA-S seems to influence antioxidant levels; IGF-1 deficiency was associated with alteration in parameters of myocardial structure and dysfunction. These data suggest a role of anabolic hormones in the complex pathophysiological mechanisms of HFpEF and could represent the basis for longitudinal studies and investigations on possible benefits of replacement therapy. |
| first_indexed | 2024-12-23T11:16:57Z |
| format | Article |
| id | doaj.art-2ed03d2129a1422786ce33df541590db |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T11:16:57Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2ed03d2129a1422786ce33df541590db2022-12-21T17:49:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-05-011110.3389/fendo.2020.00281523747Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial DysfunctionCarmine Bruno0Carmine Bruno1Andrea Silvestrini2Andrea Silvestrini3Rodolfo Calarco4Rodolfo Calarco5Angela M. R. Favuzzi6Angela M. R. Favuzzi7Edoardo Vergani8Edoardo Vergani9Maria Anna Nicolazzi10Maria Anna Nicolazzi11Claudia d'Abate12Claudia d'Abate13Elisabetta Meucci14Elisabetta Meucci15Alvaro Mordente16Alvaro Mordente17Raffaele Landolfi18Raffaele Landolfi19Antonio Mancini20Antonio Mancini21Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyFondazione Policlinico Universitario a Gemelli IRCCS, Rome, ItalyPurpose: In heart failure with reduced ejection fraction, catabolic mechanisms have a strong negative impact on mortality and morbidity. The relationship between anabolic hormonal deficiency and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. On the other hand, oxidative stress is recognized as a player in the pathogenesis of HFpEF. Therefore, we performed a cohort study in HFpEF aimed to (1) define the multi-hormonal deficiency prevalence in HFpEF patients; (2) investigate the relationships between hormonal deficiencies and echocardiographic indexes; (3) explore the modulatory activity of anabolic hormones on antioxidant systems.Methods: 84 patients with diagnosis of HFpEF were enrolled in the study. Plasma levels of N-terminal pro-brain natriuretic peptide, fasting glucose, insulin, lipid pattern, insulin-like growth factor-1, dehydroepiandrosterone-sulfate (DHEA-S), total testosterone (T, only in male subjects) were evaluated. Hormonal deficiencies were defined according to T.O.S.C.A. multi-centric study, as previously published. An echocardiographic evaluation was performed. Plasma total antioxidant capacity (TAC) was measured using the system metmyoglobin –H2O2 and the chromogen ABTS, whose radical form is spectroscopically revealed; latency time (LAG) in the appearance of ABTS• is proportional to antioxidants in sample.Results: Multiple deficiencies were discovered. DHEA-S deficiency in 87% of patients, IGF-1 in 67% of patients, T in 42%. Patients with DHEA-S deficiency showed lower levels of TAC expressed by LAG (mean ± SEM 91.25 ± 9.34 vs. 75.22 ± 4.38 s; p < 0.05). No differences between TAC in patients with or without IGF-1 deficiency were found. A trend toward high level of TAC in patients without hormonal deficiencies compared with patients with one or multiple deficiencies was found. Regarding echocardiographic parameters, Left Atrial and Left Atrial Volume Index were significantly higher in patients with low IGF-1 values (mean ± SD 90.84 ± 3.86 vs. 72.83 ± 3.78 mL; 51.03 ± 2.33 vs. 40.56 ± 2.46 mL/m2, respectively; p < 0.05).Conclusions: Our study showed high prevalence of anabolic deficiencies in HFpEF. DHEA-S seems to influence antioxidant levels; IGF-1 deficiency was associated with alteration in parameters of myocardial structure and dysfunction. These data suggest a role of anabolic hormones in the complex pathophysiological mechanisms of HFpEF and could represent the basis for longitudinal studies and investigations on possible benefits of replacement therapy.https://www.frontiersin.org/article/10.3389/fendo.2020.00281/fullheart failurecardiovascular endocrinologyantioxidantshormonesmyocardial dysfunctions |
| spellingShingle | Carmine Bruno Carmine Bruno Andrea Silvestrini Andrea Silvestrini Rodolfo Calarco Rodolfo Calarco Angela M. R. Favuzzi Angela M. R. Favuzzi Edoardo Vergani Edoardo Vergani Maria Anna Nicolazzi Maria Anna Nicolazzi Claudia d'Abate Claudia d'Abate Elisabetta Meucci Elisabetta Meucci Alvaro Mordente Alvaro Mordente Raffaele Landolfi Raffaele Landolfi Antonio Mancini Antonio Mancini Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction Frontiers in Endocrinology heart failure cardiovascular endocrinology antioxidants hormones myocardial dysfunctions |
| title | Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction |
| title_full | Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction |
| title_fullStr | Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction |
| title_full_unstemmed | Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction |
| title_short | Anabolic Hormones Deficiencies in Heart Failure With Preserved Ejection Fraction: Prevalence and Impact on Antioxidants Levels and Myocardial Dysfunction |
| title_sort | anabolic hormones deficiencies in heart failure with preserved ejection fraction prevalence and impact on antioxidants levels and myocardial dysfunction |
| topic | heart failure cardiovascular endocrinology antioxidants hormones myocardial dysfunctions |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00281/full |
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